ACE、CYP11B2、α-adducin基因多态性与脉压的相关性研究  

Association among ACE,CYP11B2 and α-adducin gene polymorphisms with pulse pressure

作　　者：林慧中[1] 陈慧[2] 骆杰伟[2] 吴小盈[2] 陈燕[2] 李德育[2] 陈喜军[2] 

机构地区：[1]福建医科大学附属协和医院心内科,福建福州350001 [2]福建省立医院

出　　处：《心血管康复医学杂志》2009年第3期204-207,213,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

基　　金：福建省自然科学基金重点资助项目(C0420003)

摘　　要：目的:研究血管紧张素转换酶(ACE)(I/D)、醛固酮合成酶(CYP11B2)-344T/C、α-内收蛋白(α-adducin)460G/T不同基因多态性与高血压患者及正常人脉压(PP)的关系。方法:按PP<40 mmHg、40～59 mmHg、≥60 mmHg,高血压组(1081例)和血压正常组(604例)分别被分为3组,计数资料用卡方检验,计量资料用t检验或方差检验。结果:高血压组和血压正常组在二项逐步Logistic回归中,调整了其他混杂因素后,两组ACE-DD+CYP11B2-CC/TC+α-adducin-TT型和年龄均进入最后的方程;两组ACE-DD+CYP11B2-CC/TC+α-adducin-TT型与高脉压(≥60 mmHg)分别显著相关(OR值分别为3.318和4.556,P分别为0.005和0.044)。结论:在高血压患者和正常人中,同时携带有ACE基因DD型、CYP11B2基因TC/CC型和α-adducin基因TT型者脉压增大的风险要高于其他基因型组合,是脉压增大的独立危险因素。Objective： To investigate the association among ACE, CYP11B2 and α-adducin gene polymorphisms with pulse pressure （PP） in primary hypertensive and normotensive subjects. Methods： The primary hypertensive subjects （1081 cases） and normotensive subjects （604 cases） were divided respectively into three groups： PP〈40mmHg, 40-59mmHg and ≥60mmHg. Binary stepwise Logistic regression was used to analyze the relationship between gene poly-morphisms and PP, which being considered confounding factors like age, sex, etc. Results： Binary Logistic stepwise regression results demonstrated that ACE--DD＋CYP11B2-CC/TC＋α-adducin-TT genotype and age entered the model after adjusting confounding factors. ACE-DD＋CYP11B2-CC/TC＋αadducin-TT genotype was significantly associated with high pulse pressure （≥60mmHg） in both primary hypertensive （OR= 3. 318, P=0. 005） and normotensive groups （OR=4. 556, P=0. 044）. Conclusion： The risk of high PP increased in both primary hy=pertensive and normotensive subjects whom carried ACE-DD, CYP11B2-TC/CC and α-adducin TT genotypes at the same time, and this combination of genotype is the independent risk factor of high PP.

关 键 词：基因 血压 高血压 

分 类 号：R544.109[医药卫生—心血管疾病]