老年原发性高血压病与高胰岛素血症关系的研究  

Relationship between senile essential hypertension and hyperinsulinemia

作　　者：钟东塔[1] 林立勇[1] 朱震豪[1] 

机构地区：[1]福建医科大学附属协和医院急诊科,福建福州350001

出　　处：《心血管康复医学杂志》2009年第3期255-257,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨老年原发性高血压病患者血清胰岛素水平及对胰岛素的敏感性。方法:测定无糖尿病老年原发性高血压组80例、健康对照组43例的空腹血糖(FBG)、餐后2h血糖(PBG)、空腹胰岛素(FINS)和餐后2h胰岛素(PINS)水平,计算胰岛素敏感指数(ISI),并进行对比。结果:老年原发性高血压组患者FINS及PINS水平均较健康对照组显著升高[(13.5±5.0)mU/L∶(9.2±4.6)mU/L,(40.9±10.4)mU/L∶(16.1±6.9)mU/L,P<0.01],老年原发性高血压组患者ISI较对照组明显降低[(-4.2±0.3)∶(-3.4±0.3),P<0.05]。结论:老年原发性高血压患者多伴有高胰岛素血症和胰岛素抵抗。其发生与组织对胰岛素的敏感性下降,胰岛素的分泌异常增多有关。Objective： To investigate the relationship between senile essential hypertension （EH） and hyperinsulinemia. Methods： Fasting blood glucose （FBG）, postprandial blood glucose （PBG）, Fasting blood insulin （FINS） and postprandial blood insulin （PINS） were examined in 80 senile patients with EH and 43 senile healthy controls. Insulin sensitive index （ISI） was calculated. Results： Compared with healthy controls, FINS and PINS level were elevated significantly in senile patients with EH group [（13.5±5.0） mU/L：（9.2±.6） mU/L, （40.9±10.4） mU/L ： （16. 1±6.9） mU/L, P〈0.01]. ISI was lower in the EH patients than that in the controls [（-4.2±0.3）： （-3.4±0.3）, P〈0.05]. Conclusion： The results suggested that there is hyperinsulinemia and insulin resistance in the senile patients with EH. Hyperinsulinemia resulted from insulin resistance is one of significant risk factors for elevating of blood pressure.

关 键 词：高血压 高胰岛素血症 老年人 

分 类 号：R544.109[医药卫生—心血管疾病]