孕妇血清血管内皮细胞生长因子及其可溶性受体测定对子痫病情的预测及判断  

Detection of vascular endothelial growth factor and its soluble receptor in serum in the prognosis of preeclampsia

作　　者：赵淑清[1] 许小莉[1] 刘颖[1] 

机构地区：[1]浙江省台州市立医院妇产科,318000

出　　处：《中国妇幼保健》2009年第19期2708-2710,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨血管内皮生长因子(VEGF)和可溶性血管内皮生长因子受体(sFlt-1)变化与子痫发病的关系,建立一种子痫前期的早期预测和诊断方法。方法:采用酶联免疫吸附法(ELISA)检测正常妊娠孕晚期和子痫前期、子痫期孕妇血清VEGF和sFlt-1水平,比较两者水平变化与病情进展的关系。结果:与正常妊娠组比较,子痫前期组VEGF显著低于正常水平,而sFlt-1显著高于正常水平。随子痫病情加重,VEGF水平呈逐步下降趋势,而sFlt-1水平呈逐步上升趋势。结论:孕妇血清VEGF的下降和sFlt-1的上升与子痫前期的发病及病情进展密切相关,可作为子痫的早期预测和判断指标。Objective： To explore the relationship between vascular endothelial growth factor （VEGF） and its soluble receptor （ sFlt - 1 ） in serum and preeclampsia, establish a useful method to evaluate and diagnose preeclampsia. Methods： The levels of VEGF and sFlt - 1 in healthy pregnant women （ control group） in third trimester and preeclampsia patients and eclampsia patients were detected by enzyme - linked immunosorbent assay （ELISA）, the relationship between the levels of VEGF and sFlt - 1 and preeclampsia was analysed. Results： The level of VEGF in preeclampsia patients was significantly lower than that in control group, while the level of sFlt - 1 reversed. The level of VEGF decreased and the level of Flt - 1 increased with the development of preeclampsia. Conclusion： The down regulation of VEGF and up regulation of sFlt - 1 are related to the pathogenesis and prognosis of preeclampsia, which is a useful diagnostic marker of preeelampsia.

关 键 词：子痫前期 血管内皮生长因子 可溶性血管内皮生长因子受体 判断指标 

分 类 号：R714.245[医药卫生—妇产科学]