女性生殖器尖锐湿疣复发与Th1/Th2细胞因子的关系  

The relationship between recrudescence of female genital condyloma acuminate and Th1/Th2 cytokines

作　　者：涂权梅[1] 吕杰强[1] 沙圣芬[1] 陈小鸣[1] 杨安素[1] 

机构地区：[1]温州医学院附属第二医院妇产科,浙江温州325027

出　　处：《中国妇幼保健》2009年第19期2718-2719,共2页Maternal and Child Health Care of China

基　　金：温州市科技局基金资助(Y20060299);温州医学院附属二院院内课题

摘　　要：目的:观察女性生殖器尖锐湿疣复发与不复发患者的外周血Th1/Th2细胞因子水平,探讨其复发与其外周血Th1/Th2细胞因子的关系。方法:选取女性生殖器尖锐湿疣初发患者37例,经电灼治疗后随访3个月(期间不使用任何免疫制剂),根据是否复发分为复发A组15例和未复发B组22例。用ELISA法测定电灼治疗前各血清标本的细胞因子IL-2、IL-12、IL-4、IL-10的浓度,比较A、B两组血清各细胞因子及Th1/Th2比值的差异,分析尖锐湿疣复发与血清Th1/Th2细胞因子水平的关系。结果:尖锐湿疣复发与Th1/Th2比值呈显著负相关性。结论:尖锐湿疣复发与否与患者血清Th1/Th2细胞因子水平呈密切负相关。Objective： To observe and explore the relationship between relapse of female genital eondyloma acuminate and Th1/ Th2 cytokines in peripheral blood. Methods ： 37 cases with genital condyloma acuminate were treated by electric cautery for 3 months, then they were divided into two groups： A group （ 15 cases with recrudescence） and B group （22 cases without recrudescence） . The levels of interleukin- 2, interleukin- 12, interleukin- 4 and interleukin- 10 were detected by ELISA before and after treatment, the ratio of Th1/ Th2 was calculated, the relationship between recrudescence of female genital eondyloma acuminate and Th1/Th2 cytokines was analysed. Results： There was negative correlation between recrudescence of female genital condyloma acuminate and Th1/Th2 eytokines. Conclusion： There is negative correlation between recrudescence of female genital condyloma acuminate and Th1/Th2 cytokines.

关 键 词：女性生殖器 尖锐湿疣 细胞因子 白介素 TH1/TH2失衡 

分 类 号：R711.59[医药卫生—妇产科学]