异臭椿烷对S180肉瘤细胞小鼠移植瘤的影响  

THE EFFECT OF ISOMALABARICANE TRITERPENES ON MICE WITH TRANSPLANTED S180 SARCOMA

作　　者：邢智远[1] 宋修岐[1] 

机构地区：[1]青岛大学医学院第二附属医院普外科,山东青岛266042

出　　处：《齐鲁医学杂志》2009年第5期394-396,共3页Medical Journal of Qilu

摘　　要：目的探讨不同剂量的异臭椿烷治疗S180肉瘤细胞小鼠皮下移植瘤效果。方法建立S180肉瘤细胞小鼠皮下移植瘤动物模型,随机分为空白对照组、阳性对照组、异臭椿烷高、中、低剂量组,每组9只。异臭椿烷高、中、低剂量组分别给予1.0、0.5、0.1mg/L异臭椿烷0.1mL,灌胃给药,每天1次;阳性对照组采用环磷酰胺腹腔注射给药,25mg/(kg·d);空白对照组每只给予0.1mL纯食用油灌胃。5组均连续给药5d后间隔2d再次连续给药5d。停药后24h处死小鼠,称取小鼠体质量,比较小鼠实验前后体质量变化;称取瘤质量,计算抑瘤率。结果异臭椿烷各剂量组和阳性对照组小鼠状态总体表现明显强于空白对照组,体质量增加幅度明显高于空白对照组,肿瘤生长速度明显慢于空白对照组,差异均有显著意义(F=34.786、16.407,q=3.059～16.077,P<0.05)。结论异臭椿烷对S180肉瘤细胞小鼠皮下移植瘤生长具有一定的抑制作用。Objective To explore the anti-tumor effect of isomalabaricane triterpenes （IT） in mice with transplanted subcutaneous S180 sarcoma. Methods A subcutaneous transplanted model of S180 sarcoma in mice was made. The mice were divided into five groups： blank-control, positive control, IT high dosage （ITH）, IT medium-dosage （ITM） and IT-low-dosage （ITL）, nine mice in each group. IT （0. 1, 0. 5, 1.0 mg/L） was given to ITL, ITM and ITH, respectively, by intragastric medication, once a day; endoxam 25 mg/（kg · d） was intraperitoneally injected to the positive-control; and edible oil was lavaged for the blankcontrol. The medication was successive for five days, then discontinued for two days, and followed for five more days. The mice were sacrificed 24 hours after drug withdrawal. The weight of the mice and the tumors were measured. The tumor inhibition rate was calculated. Results General conditions of the mice in IT groups and the positive-control were much better than those in the blank-control, and the growthof tumor was slower, with a significant difference （F=34.786,16.407;q=3. 059-16.077;P〈0. 05）. Conclusion Isomalabaricane triterpenes can inhibit the growth of subcutaneous transplanted S180 sarcoma in mice.

关 键 词：异臭椿烷 皮下移植瘤 抑瘤率 

分 类 号：R931.77[医药卫生—生药学]