非小细胞肺癌组织Fas、FasL和Bcl-2表达及意义  

EXPRESSIONS OF Fas,FasL,AND Bcl-2 IN NON-SMALL CELL LUNG CANCER AND THEIR CLINICAL SIGNIFICANCE

作　　者：牟宗宝[1] 沈毅[1] 杨景伟[1] 

机构地区：[1]青岛大学医学院附属医院胸外科,山东青岛266003

出　　处：《齐鲁医学杂志》2009年第5期397-399,402,共4页Medical Journal of Qilu

摘　　要：目的探讨Fas、FasL和B细胞淋巴瘤因子2(Bcl-2)蛋白在非小细胞肺癌组织的表达及临床意义。方法用免疫组化EnVison法检测60例非小细胞肺癌组织Fas、FasL和Bcl-2蛋白的表达,并分析其与病理分期、肿瘤分化和淋巴结转移的关系。同时,取癌旁5cm以上正常肺组织18例作为对照。结果Fas、FasL和Bcl-2蛋白在非小细胞肺癌组织中的表达与癌旁肺组织相比差异有显著性(Hc=12.26～37.07,P<0.01)。Fas蛋白的表达与肿瘤TNM分期、分化程度及淋巴结转移相关(Hc=20.21、18.31,u=-3.38,P<0.01);FasL蛋白的表达也与肿瘤TNM分期、分化程度及淋巴结转移相关(Hc=15.09、8.61,u=-2.16,P<0.05);Bcl-2蛋白的表达与肿瘤TNM分期、分化程度及淋巴结转移相关(Hc=14.15、8.84,u=-3.03,P<0.01)。结论Fas、FasL及Bcl-2蛋白表达失衡与非小细胞肺癌的发生发展密切相关。Objective To explore the expressions of Fas, FasL and Bcl-2 in non-small cell lung cancer （NSLC） and their clinical significance. Methods EnVison immunohistochemical method was used to examine the expressions of Fas, FasL and Bcl- 2 in 60 NSLC patients, the relationship between the expressions and pathologic staging, differentiation, and lymph node metastasis were analyzed. The normal tissue 5 cm away from the cancer was taken from 18 cases served as controls. Results The differences of expressions of Fas, FasL and Bcl- 2 between cancer tisue and paraneoplastie were significant （ H c= 12. 26 - 37. 07, P〈 0.01）, their expressions were correlated with TNM staging, differentiation and lymphatic metastasis, respectively （Hc = 20.21, 18.31,u=-3. 88,P〈0. 01 ; Hc=15.09,8.61,u=-2.16,P〈0. 05; and Hc=14.15,8.84,u=-3.03,P〈0. 01）. Conclusion Disbalance of the expressions of Fas, FasL and Bcl- 2 is closely associated with the occurrence and development of non small cell lung cancer.

关 键 词：癌 非小细胞肺 抗原 CD95 蛋白质BCL-2 

分 类 号：R655.3[医药卫生—外科学]