来氟米特与环磷酰胺治疗HSPN效果比较  

LEFLUNOMIDE AND CYCLOPHOSPHAMIDE:A COMPARISON OF THEIR EFFICACY FOR HENOCH-SCHONLEIN PURPURA NEPHRITIS

作　　者：王一冰[1] 李强[1] 李晶[1] 鹿松 

机构地区：[1]青岛市妇女儿童医疗保健中心内二科,山东青岛266011

出　　处：《齐鲁医学杂志》2009年第5期424-426,共3页Medical Journal of Qilu

摘　　要：目的比较来氟米特(LEF)与环磷酰胺(CTX)静脉冲击治疗肾病综合征型紫癜性肾炎(HSPN)的疗效。方法将37例肾病综合征型HSPN病儿随机分为两组:LEF组(n=19)用糖皮质激素(激素)联合LEF治疗,CTX组(n=18)行激素联合CTX冲击治疗,观察两组疗效及治疗6、12个月时尿蛋白及血尿的变化。结果两组临床疗效比较差异无显著性(P>0.05)。治疗6个月时血尿缓解率LEF组高于CTX组(χ2=5.43,P<0.05)。结论与CTX结合小剂量激素治疗相比较,LEF结合小剂量激素治疗肾病综合征型HSPN有相近的临床缓解率;而在缓解血尿方面,LEF较CTX更为有效。Objective To compare the effects of leflunomide （LEF） and cyclophosphamide （CTX） in the treatment of Henoch Schonlein purpuric nephritis （HSPN） with nephrotic syndrome. Methods Thirty seven children with nephrotic syndrome HSPN were divided into two groups, LEF and CTX groups, in random. The patients in LEF group （19 cases） were treated with combined hormone with I.EF; and those in CTX group （18 cases） treated with hormone and CTX. Proteinuria and hematuria were followed after six and 12 months of medication. Results The clinical effects between the two groups did not show signifi cant difference （P〉0.05）. The remission rate of hematuria in LEF group was higher than CTX group in six mouth treatment （x^2 = 5.43, P〈0.05）. Conclusion A comparison indicates that combined therapy of CTX or LEF, both with low dose hormone, for nephrotic syndrome HSPN has similar effectiveness, but LEF is more effective than CTX in terms of relief of hematuria.

关 键 词：来氟米特 环磷酰胺 紫癜性肾炎 肾病综合征 儿童 

分 类 号：R725.93[医药卫生—儿科]