类风关1号对佐剂关节炎大鼠滑膜VEGF和COX-2表达的影响  

Effects of Rheumatoid Arthritis No.1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis

作　　者：张彦[1] 宋欣伟[1] 吴玲燕[1] 康海英[1] 孙伟[1] 

机构地区：[1]浙江中医药大学附属第一医院风湿免疫科,杭州310006

出　　处：《天津中医药》2009年第3期230-232,共3页Tianjin Journal of Traditional Chinese Medicine

基　　金：浙江省自然科学基金资助项目(205677)

摘　　要：[目的]探讨类风关1号对佐剂关节炎(AA)大鼠滑膜血管内皮细胞生长因子(VEGF)和环氧化酶2(COX-2)表达的影响。[方法]建立AA大鼠模型,并给予类风关1号灌胃4周,以免疫组化法检测滑膜组织中VEGF和COX-2的表达。[结果]灌胃4周后类风关1号组大鼠膝关节滑膜VEGF和COX-2表达水平明显降低,与AA模型组及雷公藤多苷组相比差异意义有显著性(P<0.01)。[结论]类风关1号可明显抑制滑膜组织中VEGF和COX-2的表达,减轻关节病理性血管增生。[Objective] To explore the effects of Rheumatoid Arthritis No. 1 on expression of VEGF and COX-2 in synovial membrane in rats with adjuvant arthritis （AA）. [Methods] The model of adjuvant arthritis was established in rats. After administration by Rheumatoid Arthritis No. 1, for 4 weeks the immunohistochemical method was used to detect the expression of VEGF and COX-2 in synovial mem- brane of rats. [Results] The expression of VEGF and COX-2 in Rheumatoid Arthritis No. 1 group was significantly decreased compared to the groups of model and tripterygium wilfordii （P〈0.01）. [Conclusion] Rheumatoid Arthritis No. 1 can significantly inhibit the expression of VEGF and COX-2 in synovial membrane of rate with adjuvant arthritis, reduce the inflammation of knee joint.

关 键 词：类风湿关节炎 大鼠 血管内皮细胞生长因子 环氧化酶 

分 类 号：R285.5[医药卫生—中药学]