两种语言任务的功能磁共振成像研究  

Study of functional MRI of two language tasks in normal subjects

作　　者：熊晓双[1] 杜滂[1] 杨兰英[1] 李强[1] 王玮[1] 

机构地区：[1]第四军医大学唐都医院放射科,陕西西安710038

出　　处：《西南国防医药》2009年第6期561-563,共3页Medical Journal of National Defending Forces in Southwest China

基　　金：陕西省科技攻关项目[2004K12-G3(3)]

摘　　要：目的:研究母语为汉语的正常成年人在完成两种语言任务时的功能磁共振激活表现,为研究语言功能区定位的方法提供参考依据。方法:使用3.0T磁共振对12例右利手、母语为汉语的正常志愿者行词语联想、动词产生任务时的脑部fMRI成像。采用SPM5软件进行数据处理和分析,得到脑功能激活图,并计算偏侧化指数。结果:词语联想和动词产生任务共同激活双侧额下回、前扣带回、辅助运动区、左侧额中回、中央前回、基底节区部分核团、双侧岛叶、枕叶及小脑;激活图及偏侧化指数均显示,两种语言任务呈现明显的左半球偏侧化;左侧额下回Broca区均显著激活。结论:汉语词语联想、动词产生任务的fMRI成像均表现为左半球优势,且有效激活Broca区;fMRI成像是脑外科术前研究语言功能定位的可行方法之一。Objective：To investigate the activated brain imaging of functional magnetic resonance in normal adult subjects whose native language was Chinese and provide referred information for selecting proper methods to localize language area. Methods ： Twelve right - handed normal volunteers whose native language was Chinese participated in this study. They underwent functional magnetic resonance imaging （fMRI） scanning inside a 3.0 T MR scanner when performing the word generation and the verb generation task,respectively. The SPM5 software was used to handle and analyze the data to obtain functional activated brain imaging, and calculate the lateralization indexes. Results：The bilateral inferior frontal gyms,anterior eingutate, supplementary motor area, left middle frontal gyrus, precentral gyrus, partial nuclear groups of basal ganglia, bilateral insula,occipital lobe and cerebellum were strongly activated in the processes of both word generation and verb generation. The activated brain imaging and lateralization indexes indicated a significant lateralized activation of left hemisphere. Conclusion ： The brain imaging demonstrates left hemisphere superiority in the processes of word generation and verb generation in Chinese. Furthermore,the Broca＇s area was effectively activated by both of the two tasks above - mentioned, fMRI can be used as one of feasible methods to investigate the localization of language area.

关 键 词：语言 功能磁共振成像 词语联想 动词产生 定位 

分 类 号：R445.2[医药卫生—影像医学与核医学]