川南地区乙型肝炎病毒基因型的分布及临床意义  

Distribution of HBV genotypes in southern Sichuan area and its clinical significance

作　　者：赖辉[1] 陈涛[1] 候莉[1] 范鹏程[1] 王道理[2] 张建军[2] 

机构地区：[1]四川省广元市第一人民医院感染病科,四川广元428017 [2]泸州医学院附属医院感染病科,四川泸州646000

出　　处：《西南国防医药》2009年第6期581-584,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的:初步了解乙型肝炎病毒基因型的分布及临床意义。方法:用特异性引物-聚合酶链反应的方法,对80例来自川南地区HBV-DNA阳性慢性乙型肝炎病毒感染者血清进行HBV基因分型,其中无症状携带者26例,轻、中度慢性肝炎35例,重型肝炎、肝硬化13例及肝癌6例。结果:80例血清标本中,B型64例(80%),C型12例(15%),B+C混合基因型4例(5%)。B型平均年龄低于C型(P<0.01);B型的HBeAg阳性率高于C型(P<0.01),HBV-DNA水平也高于C型(P<0.05);B、C型在肝功能损伤程度指标的比较无统计学意义(P>0.05)。结论:川南地区主要的HBV基因型为B型和C型,B型为优势基因型,还有少量的B+C混合型;HBV基因型与其致病性有一定的相关性。Objective：To investigate preliminarily the distribution of hepatitis B virus （HBV） genotypes in southern Sichuan area and its clinical significance. Methods： Nested PCR with genotype - specific primers was employed to study the 80 serum specimen collected from chronic HBV infected individuals with positive HBV - DNA in southern Sichuan area including 26 cases of asymptomatic HBV carrier,35 cases of mild or moderate chronic hepatitis, 13 cases of severe hepatitis or cirrhosis of liver and 6 cases of hepatocellular carcinoma. Results： Among the 80 individuals ,64 cases were genotype B （ 80% ）, 12 cases were genotype C （ 15% ） and 4 cases were BC mixed - genotype （ 5% ）. Average age of individuals with genotype B was younger than those with genotype C （ P 〈 0.01 ） while positive rate of HBeAg and serum level of HBV - DNA were higher than those with genotype C （ P 〈 0.01 ;P 〈 0.05 ）. There were no significant differences of indexes related to liver function damage （ ALT, AST and TBIL） between genotype B and C. Conchlksion：The HBV genotype in southern Sichuan area was type B and C besides small quantity of BC mixed - genotype, and genotype B is dominant. The HBV genotype is associated with its pathogenicity to some extent.

关 键 词：乙型 肝炎病毒 基因型 聚合酶链反应 地区分布 

分 类 号：R512.6[医药卫生—内科学]