妊娠高血压综合征患者胰岛素样生长因子与胎儿发育的关系  

The relationship between insulin-like growth factor and fetal development in patients with pregnancy-induced hypertension syndrome

作　　者：盛霞玲 

机构地区：[1]广东省惠阳妇幼保健院妇产科,广东惠阳516001

出　　处：《中国医药导报》2009年第19期15-16,共2页China Medical Herald

摘　　要：目的:探讨妊娠高血压综合征患者血清胰岛素样生长因子-1(IGF-1)和胰岛素样生长因子结合蛋白-3(IGFBP-3)水平与疾病程度及新生儿出生体重之间的关系。方法:用放射免疫方法测定40例妊娠高血压综合征患者和40例正常血压妊娠妇女的血清IGF-1及IGFBP-3水平。结果:重度妊娠高血压综合征组IGF-1显著低于正常组,IGFBP-3在各组间的水平均无显著性差异,但IGF-1与IGFBP-3呈正相关。新生儿出生体重随妊娠高血压综合征严重程度的加剧而降低,各组间比较,有显著性差异(F=5.453,P=0.002)。结论:妊娠高血压综合征患者的发病及严重程度与IGF-1明显相关,IGF-1与胎儿的发育及新生儿出生体重有明显的相关性。Objective： To explore the relationship between levels of serum insulin-like growth factor 1（IGF-1） and insulin-like growth factor binding protein 3 （IGFBI-3） in women with pregnaney-induced hypertension syndrome （PIH） and severity of PIH as well as the neonatal birth weight. Methods： Radioimmunoassay was used to detect levels of serum IGF-1 and IGFBP-3 in 40 easess with PIH and 40 cases of normal pregnancy women. Results： The level of serum IGF-1 in severe PIH group was signifieantly lower than that of normal group. There was no significant difference in IGFBP-3 among groups, but there was a positive correlation between IGF-1 and IGFBP-3. The neonatal birth weight reduced with the PIH severity aggravated and there was a signifieant difference among groups （F=5.453, P=0.002）. Conclusion： The occurrence and severity of patients with PIH are obviously related to IGF-1, and IGF-1 shows an obvious correlation with fetal development and neonatal birth weight.

关 键 词：妊娠高血压综合征 胰岛素样生长因子 胰岛素样生长因子结合蛋白-3 胎儿 

分 类 号：R714.246[医药卫生—妇产科学]