玻璃酸钠在滴眼剂中的最佳用量  

The optimal dosage of sodium hyaluronate in eye drops

作　　者：段韵[1] 吴培源 朱祖驰 陈燕 

机构地区：[1]江西省人民医院药剂科,江西南昌330006 [2]江西省婺源县人民医院药剂科,江西婺源333200 [3]江西博士达药业有限公司,江西上高336400

出　　处：《中国医药导报》2009年第19期88-89,共2页China Medical Herald

摘　　要：目的:通过试验摸索玻璃酸钠在滴眼剂中适合工艺生产与临床需要的用量。方法:梯度测定玻璃酸钠甘油溶液通过0.22μm滤膜时的滤速及动力黏度。结果:玻璃酸钠浓度大于0.03%的甘油溶液很难通过滤芯;大于0.02%时虽能通过但滤速不理想;等于0.02%时滤速接近设计值,制成品经临床验证可靠;各浓度梯度玻璃酸钠甘油溶液动力黏度差异不大。结论:在滴眼剂中,玻璃酸钠与甘油的比例为1∶2～1∶4,玻璃酸钠最佳用量为0.02%。Objective： To explore the optimal dosage of sodium hyaluronate in eye drops, suitable for production and clinical use. Methods： The dynamic viscosity of sodium hyaluronate solution was determined by passing 0.22μm filter membrane. Results： It＇s difficult for more than 0.03% sodium hyaluronate solution to pass the filter element, more than 0.02% sodium hyaluronate could pass the filter member, but its speed was not very suitable. The speed of 0.02% sodium hyaluronate was close to the hypothesis and its product had passed clinical verification. There was no significant difference in the dynamic viscosity among the different sodium hyaluronate solutions. Conclusion： The proportional region of sodium hyaluronate and glycerine is from 1：2 to 1：4 in eye drops and the optimal dosage of sodium hyaluronate is 0.02% based on the study of production and clinics.

关 键 词：玻璃酸钠 最佳用量 滴眼剂 

分 类 号：R94[医药卫生—药剂学]