机构地区:[1]河北医科大学第二医院眼科,石家庄050000
出 处:《中华眼科杂志》2009年第3期243-247,共5页Chinese Journal of Ophthalmology
摘 要:目的探讨中心性浆液性脉络膜视网膜病变(CSC)患者眼球后血管血流动力学变化特征、脉络膜循环异常特点及其与视网膜色素上皮病变的关系。方法病例对照研究。应用彩色超声多普勒检测57例(57只患眼,57只对侧眼)CSC单侧受累患者及25例(50只眼)正常对照者的眼动脉、睫状后动脉、睫状后短动脉,记录其血管收缩期峰值血流速度(PSV)和舒张末期血流速度(EDV)及阻力指数(RI),并对CSC患者的患眼、对侧眼及正常对照眼的血流参数两两间分别进行比较研究。采用海德堡激光扫描眼底造影系统,对57例患者行同步吲哚氰绿脉络膜血管造影(ICGA)、荧光素眼底血管造影(FFA),并对其图像进行对比分析。采用SPSS12.0统计学软件。对CSC患者的患眼与对侧眼的眼动脉、颞侧睫状后动脉、颞侧睫状后短动脉的PSV、EDV、RI血流参数进行比较,采用自身配对t检验;对正常对照眼与CSC患者的对侧眼和患眼血流参数进行比较,采用成组设计t检验。以P〈0.05作为差异有统计学意义。结果CSC患者的患眼和正常对照者的颞侧睫状后动脉(PSV:t=3.044,P=0.005;EDV:t=3.731,P=0.001)、颞侧睫状后短动脉(PSV:t=2.822,P=0.008;EDV:t=3.194,P=0.003),患者对侧眼和正常对照者的颞侧睫状后动脉(PSV:t=3.219,P=0.003;EDV:t=3.807,P=0.001)、颞侧睫状后短动脉(PSV:t=3.931,P=0.000,EDV:t=3.145,P=0.003)血流参数均下降,差异有统计学意义(P〈0.05)。患者的患眼与对侧眼的颞侧睫状后动脉(PSV:t=0.608,P=0.548;EDV:t=0.122,P=0.904)、颞侧睫状后短动脉(PSV:t=0.730,P=0.470;EDV:t=0.109,P=0.914)的血流参数比较,差异均无统计学意义(P〉0.05)。ICGA、FFA检查结果显示,57例患者的患眼所有视网膜色素上皮渗漏点均出现在相对应的Objective To analyze the characteristics of the retrobulbar blood vessels' hemedynamics changes and the choroidal circulation disorder, and to observe the relations between retinal pigment epithelium's(RPE) pathological changes and them. Methods It was a case control study. For 57 (57 affected eyes and 57 contralatcral eyes) unilateral eye affected patients and 25(50 eyes) normal health adults, we examined ophthalmic arteries (OA), posterior ciliary arteries (PCA) and short posterior ciliary arteryies (SPCA) by color Doppler flow Imaging (CDFI) , and recorded the peak systolic velocities ( PSV), end diastolic velocities (EDV) and resistance indexes (RI) of them. We compared each hemodynamic parameter of the normal eyes with it of the affected eyes and contralateral eyes in patients group respectively, and contrasted them between affected eyes and contralateral eyes of the patients. Fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were performed simultaneously on 57 patients with Heidelberg retina angiography, and the images were analyzed in contrast. We used SPSS 12. 0 statistics software was used in the study. To the PSV, EDV and RI of the OA, PCA and SPCA in affected eyes and contralateral eyes of the patients, we used paired t-test for the same sample to compare their hemodynamic parameters; to compare normal health adults' eyes with the affected eyes and the contralateral eyes of patients group respectively, we used two-group t-test. When the P-value was less than 0. 05, there was a statistical significance. Results There was a more significant decrease of the hemodynamic parameters in both PSVs and EDVs of temporal PCAs ( PSV : t = 3. 044, P = 0. 005 ; EDV : t = 3. 731 ,P = 0. 001 ) and temporal SPCAs ( PSV : t = 2. 822, P = 0. 008 ; EDV : t = 3. 194, P = 0. 003 ) compared the patients group's affected eyes with normal health adults group eyes, there was a more significant decrease of them of temporal PCAs �
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