Fmr1基因敲除小鼠脏器重量和脏器系数的比较分析  

Determination of Weight of Internal Organs in Fmr1 Knockout Mice

作　　者：戴丽军[1] 叶炳飞[1] 黄月玲[1] 

机构地区：[1]广州医学院实验动物中心,广州510182

出　　处：《中国比较医学杂志》2009年第6期59-61,共3页Chinese Journal of Comparative Medicine

基　　金：广东省科技计划重点攻关项目(200560302004);广州医学院科研课题(04-K-53)

摘　　要：目的通过对Fmr1基因敲除小鼠雌雄两性和FVB小鼠的脏器重量和脏器系数进行比较分析,了解其脏器重量的差异,探讨Fmr1基因对动物生长发育等方面的影响。方法分别测定Fmr1基因敲除小鼠雌雄两性和FVB小鼠内脏器官的绝对重量和脏器系数,并进行统计学处理和分析。结果相同年龄的Fmr1基因敲除小鼠雄性的体重、心、肺、肝和肾的绝对重量均极显著的大于雌性(P<0.01)。雌雄间脏器系数除肾脏(P<0.05)和脑(P<0.01)外,其余无显著差异。与FVB小鼠比较,Fmr1基因敲除小鼠心脏较轻(P<0.01),肾脏(P<0.01)、体重和脑较重(P<0.05)。脏器系数肾脏较大(P<0.01),心脏(P<0.01)、脑和脾(P<0.05)较小。结论Fmr1基因可影响动物的某些脏器重量和脏器系数。Objective To measure the weight of internal organs of FVB mice and Fmrl knockout mice in different sex. Methods Electronic balance was used to determine the weight of different organs and bodies and the values were analyzed statistically. Results The body weight and weights of the heart, lung, liver and kidney showed in males were higher than in females of Fmr! knockout mice （P 〈 0.01 ）;between the male and female the difference of the coefficient of brain was very significant （P 〈 0.01 ）;the difference of the coefficient of kidney was statistically significant （P 〈 0.05 ）. Compared with FVB mice, in Fmrl knockout mice the weights of heart and kidney were decreased very significantly （ P 〈 0.01 ） ; the body weight and brain were increased significantly （ P 〈 0.05） ; the coefficient of kidney was increased very significantly （ P 〈 0.01 ） and the coefficient of heart were decreased very significantly （P 〈 0.01）,the coefficients of brain and spleen were decreased significantly （P 〈 0. 05 ）. Conclusions The weight of some main organs and organ coefficient in Fmrl knockout mice are significantly different. Fmrl gene perhaps can influence the weight of some main organs and organ coefficient of animals.

关 键 词：基因剔出 FMR1 小鼠 脏器重量 脏器系数 

分 类 号：R332[医药卫生—人体生理学]