可移植假发组织相容性实验研究  

Histocompatibility of a polypropylene matrix for hair follicle transplantation in rabbits

作　　者：张志丹[1] 胡志奇[1] 易斌[1] 

机构地区：[1]南方医科大学南方医院整形科,广东广州510515

出　　处：《南方医科大学学报》2009年第6期1144-1146,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(308726927)

摘　　要：目的通过实验研究观察可移植假发的组织相容性。方法应用医用高分子材料聚丙烯的理化特性,制作成一种可移植假发的基座。实验动物选择5只新西兰白兔,在每只白兔颈部皮下采用毛囊单位移植技术,植入40束假发移植物,并分别于移植后第1周、第1～6个月内每个月在无菌条件下,每只白兔分次采集包含有移植物的全层皮肤组织,进行HE染色光学显微镜和扫描电镜组织学观察。结果移植术后第1周,可观察到移植物周围组织有局限的少量炎症细胞及淋巴细胞浸润,增生的毛细血管轻度充血,炎症反应轻微;术后1～6个月,移植物周围可见炎症反应细胞及淋巴细胞明显减少至消失,无观察到溶解、坏死等不良排斥反应,可见大量胶原纤维围绕包裹假发移植物。结论可移植假发与白兔皮下组织相容性良好,未见不良反应,为后期的动物实验及临床试验奠定了理论基础。Objective To observe the histocompatibility of a polypropylene matrix implanted subcutaneously for potential hair follicle transplantation in rabbits. Method The polypropylene matrix for harboring the hair follicles was prepared and implanted subcutaneously at the neck of 5 New Zealand white rabbits by means of hair follicle unit transplantation. At 1 week after the transplantation and then on a monthly basis in the following 6 months, full-thickness skin tissues were sampled at the site of grafting to evaluate the histocompatibility of the matrix material using HE staining and scanning electron microscopy. Result At 1 week after implantation of the matrix material, a small number of inflammatory cells and lymphocytic infiltration were observed around the graft, with mild hyperemia in the proliferative capillaries and mild inflammatory responses. In the following 6 months, the inflammatory cells and lymphocytes around the graft decreased obviously or even disappeared, and such graft rejection responses as tissue lysis and necrosis were not observed. A large quantity of collagen fibers were found to encapsulate the polypropylene material. Conelusion Polypropylene matrix graft has good histocompatibility with the rabbit subcutaneous tissue without producing obvious graft rejection responses, suggesting its feasibility for further experiments of hair follicle transplantation.

关 键 词：可移植假发 毛发移植 皮肤 聚丙烯 组织相容性 

分 类 号：R318.08[医药卫生—生物医学工程]