丙泊酚和异氟烷对老年患者术中应激反应和术后认知功能恢复的影响  

Effect of propofol and isoflurane on surgical stress response and postoperative cognitive function in elderly patients

作　　者：谭嵘[1] 

机构地区：[1]中南大学湘雅二医院麻醉科,湖南长沙410011

出　　处：《南方医科大学学报》2009年第6期1247-1248,共2页Journal of Southern Medical University

摘　　要：目的探讨丙泊酚和异氟烷麻醉对老年患者术中应激反应及术后认知功能恢复的影响。方法上腹部手术老年患者60例,分别接受丙泊酚(30例)和异氟烷(30例)麻醉,比较两组术中应激反应、术后简易精神状态量表评分、术后认知功能障碍发生率。结果丙泊酚组应激反应较异氟烷组平稳,术后简易精神状态量表评分恢复较异氟烷组快,术后认知功能障碍发生率较异氟烷组低。结论丙泊酚能有效抑制全麻术中应激反应,对患者术后认知功能影响小,适用于老年患者麻醉。Objective To investigate the effect of propofol and isoflurane on surgical stress response and postoperative cognitive function in elderly patients. Methods Sixty elderly patients scheduled for elective upper abdominal surgery with general anesthesia were randomized equally into propofol group and isoflurane group. The surgical stress response, postoperative Mini-mental State Examination （MMSE） and the rate of postoperative cognitive dysfunction （POCD） were compared between the two groups. Results The surgical stress response in propofol group was relatively stable. Compared with isoflurane group, the patients in propofol group showed significantly faster recovery of the MMSE scores with also lower rate of POCD. Conclusion Compared with isoflurane, propofol intravenous anesthesia is associated with rapid recovery of the cognitive function, stable surgical stress response and reduced adverse effects in elderly patients.

关 键 词：丙泊酚 异氟烷全麻 应激反应 认知功能 老年 

分 类 号：R614.2[医药卫生—麻醉学]