常规IVF受精失败后转ICSI与直接ICSI的临床结局比较  

Clinical outcomes of intracytoplasmic sperm injection (ICSI) and ISCI following fertilization failure in conventional IVF:a comparative analysis

作　　者：孙丽[1] 刘萍[1] 全松[1] 

机构地区：[1]南方医科大学南方医院妇产科生殖医学中心,广东广州510515

出　　处：《南方医科大学学报》2009年第5期993-995,共3页Journal of Southern Medical University

摘　　要：目的探讨常规体外受精(IVF)-胚胎移植受精失败后再次助孕治疗转卵泡浆内单精子注射(ICSI)的临床效果。方法自2007年1月至2007年12月对27例因女方输卵管因素行常规IVF受精失败的患者再次助孕治疗转为ICSI(A组),并与同期57例因男方因素而用射出精液直接行ICSI(B组)进行临床结局的比较。结果A组ICSI前、后的受精率分别为(32.3±30.3)%和(80.4±16.6)%(P<0.01);A组平均每周期正常受精率、优良胚胎率、临床妊娠率分别为(77.14±15.98)%、(28.68±23.86)%和48.1%,B组平均每周期正常受精率、优良胚胎率、临床妊娠率分别为(70.59±21.53)%、(27.18±23.97)%和54.4%,两组间比较无显著性差异(P>0.05);A组胚胎分裂率、移植胚胎数分别为(96.66±6.55)%、(2.67±0.56)个,而B组胚胎分裂率、移植胚胎数分别为(92.33±19.41)%、2.12±0.57个,两组间比较有显著性差异(P<0.05)。结论常规IVF受精失败后再次助孕治疗转ICSI可显著提高受精率,改善临床结局。Objective To evaluate the clinical outcomes of intracytoplasmic sperm injection （ICSI） in patients with previous fertilization failure in conventional in vitro fertilization （IVF） procedures. Methods Between January 2007 and December 2007, 27 ICSI cycles following a previous fertilization failure in conventional IVF （group A） and 57 direct ICSI cycles using ejaculated spermatozoa （group B） were performed, and the clinical outcomes of the two groups were analyzed. Results The fertilization rate per cycle of ICSI following a fertilization failure in conventional IVF was significantly higher than that of conventional IVF [（80.4±16.6）% vs （32.3±30.3）%, P〈0.01]. The normal fertilization rate, high-quality embryo rate, clinical pregnancy rate per cycle in group A showed no significant differences from those in group B [（77.14±15.98）% vs （70.59± 21.53）%, （28.68±23.86）% vs （27.18±23.97）%, and 48.1% vs 54.4%, respectively, P〉0.05]. The cleavage rate and transferable embryos per cycle in group A were significantly higher than those in group B [（96.66±6.55）% vs （92.33±19.41）%, 2.67±0.56 vs 2.12 ±0.57, respectively, P〈0.05]. Conclusion ICSI after a previous fertilization failure of conventional IVF may significantly improve the fertilization rate and clinical outcomes of a second IVF-ET cycle.

关 键 词：体外受精 卵细胞浆内单精子注射 受精障碍 控制性超排卵 

分 类 号：R714.8[医药卫生—妇产科学]