一氧化氮合成酶抑制剂L-NAME对妊娠大鼠心血管自主神经调节的影响  

Changes in cardiovascular autonomic control in chronic L-NAME treated pregnant rats.

作　　者：沈婕[1] 丰有吉[1] 沈霖霖[2] 乔伟伟[3] 李笑天[1] 

机构地区：[1]复旦大学附属妇产科医院妇产科,上海200011 [2]复旦大学上海医学院病理生理系 [3]复旦大学实验动物科学部

出　　处：《现代妇产科进展》2009年第6期407-410,共4页Progress in Obstetrics and Gynecology

基　　金：上海市科委重点资助项目(No:064909006)

摘　　要：目的:研究慢性一氧化氮合成酶(NOS)抑制剂对妊娠大鼠心率变异性(HRV)、血压变异性(BPV)和压力反射敏感性(BRS)的影响。方法:测定清醒、自由活动状态下一氧化氮合成酶(NOS)抑制妊娠SD大鼠和妊娠对照SD大鼠的HRV、BPV和自发性BRS;静脉注射去氧肾上腺素(5μg/kg)测定压力反射对心率的控制功能(BRSHR)。结果:NOS受抑制的妊娠大鼠与对照组相比,HRV低频成分降低(P<0.05),总的BPV及BPV的极低频成分增加(P<0.05),自发性BRS及BRSHR均明显降低(P<0.05)。结论:NO缺乏引起的心血管自主神经调节的变化是引起妊娠大鼠血压升高的原因之一。Objective：To determine the effect of chronic nitric oxide synthase inhibition on cardiovascular autonomic control in pregnant SD rat. Method：Blood pressure, heart rate and their variabilities were measured in conscious, unstrained rats, pregnant rats and chronic Nnitro-L-arginine methyl ester （L-NAME） treated pregnant rats. BRS of heart rate control （BRSHR） was measured by using a bolus intravenous injection of phenylephrine （5 μg/kg）. Results：LF of HRV as well as spontaneous BRS and BRSHR attenuated（ P 〈 0.05 ）, total BPV and VLF of BPV augmented （ P 〈 0.05 ） in L-NAME pregnant rats compared with controls. Conclusion：Changed autonomic regulation by nitric oxide deficiency, at least in part, is the etiological factor of hypertension in pregnant rat.

关 键 词：心率变异性 血压变异性 压力反射敏感性 一氧化氮 大鼠 Sprague-Dawley 

分 类 号：R714.24[医药卫生—妇产科学]