血清PCT、CRP对未足月胎膜早破并发绒毛膜羊膜炎的诊断意义  

The value of procalcitonin determinations in the diagnostics of preterm premature rupture of membranes suspected of chorioamnionitis.

作　　者：代聪伟[1] 刘新菊[1] 陈剑敏[2] 唐增军[1] 于凤华[1] 

机构地区：[1]河北省人民医院妇产科,石家庄050051 [2]保定252医院超声检验科

出　　处：《现代妇产科进展》2009年第6期431-433,共3页Progress in Obstetrics and Gynecology

摘　　要：目的:探讨检测未足月胎膜早破(PPROM)孕妇血清降钙素原(PCT)及C-反应蛋白(CRP)浓度诊断绒毛膜羊膜炎的价值。方法:选取未足月胎膜早破患者55例,相同孕周健康孕妇40例,检测血清PCT、CRP。PPROM患者分娩后,对胎盘胎膜行病理学检查。结果:PPROM组孕妇血清中PCT、CRP阳性率高于对照组,差异有统计学意义(P<0.05);但PPROM组中有组织学绒毛膜羊膜炎与无绒毛膜羊膜炎的血清PCT、CRP无显著差异(P>0.05);PCT诊断绒毛膜羊膜炎的敏感性、特异性及阳性预测值、阴性预测值分别为60.00%、35.00%、61.76%、33.33%;CRP诊断绒毛膜羊膜炎的敏感性、特异性及阳性预测值、阴性预测值分别为57.14%、50.00%、66.67%、40.00%。结论:PPROM孕妇血清中PCT及CRP浓度升高,但其预测绒毛膜羊膜炎的价值尚需进一步研究。Objective ：To investigate and C-reactive protein concentrations（CRP） the value of maternal plasma procalcitonin（PCT） in the diagnostics of PPROM cases suspected of chorioamnionitis. Methods：PCT and CRP were measured in samples of plasma from fifty five patients with PPROM, forty healthy women with preterm gestation as control. Hematoxylin eosin （ HE ） staining of placenta were taken after delivery of PPROM cases. Results： Positive rates of PCT and CRP in pregnant women with PPROM were higher than those in control group. However, in PPROM group, PCT and CRP concentrations between the patients with and without histological chorioamnionitis were comparable. PCT concentrations predicted chorioamnionitis with a sensitivity of 60.00% ,a specificity of 35.00%, a positive predictive value of 61.76%, and a predictive value of 33.33% ,While CRP concentrations predicted chorioamnionitis with a sensitivity of 57.14% ,and a specificity of 50.00%, a positive predictive value of 66.67%, and a predictive value of 40.00%. Conclusion： In PPROM group PCT and CRP values are significantly higher than that in healthy controls in approximate gestational age. But further evaluations are necessary to establish the role of them in the diagnosis of chorioamnionitis.

关 键 词：胎膜早破 绒毛膜羊膜炎 降钙素原 C-反应蛋白 

分 类 号：R714.43[医药卫生—妇产科学]