氯胺酮复合芬太尼与吗啡复合芬太尼术后静脉镇痛比较  

Comparison of Ketamine Combining Fentanyl with Morphine Combining Fentanyl for Postoperative Intravenous Analgesia

作　　者：王月莲[1] 贾晋太[1] 张东生[1] 李春雨[1] 

机构地区：[1]长治医学院附属和平医院麻醉科,046000

出　　处：《长治医学院学报》2009年第3期208-210,共3页Journal of Changzhi Medical College

摘　　要：目的：对氯胺酮复合芬太尼与吗啡复合芬太尼术后静脉镇痛的效果和不良反应进行比较。方法：选择妇科择期手术80例，ASAⅠ级～Ⅱ级连续硬膜外麻醉，需静脉镇痛患者随机分为氯胺酮复合芬太尼组（IF组）和吗啡复合芬太尼组（MF组），每组40例。于镇痛治疗48h内进行观察并记录：生命体征、疼痛评分（VAS）、镇痛满意度以及副作用等。结果：两组病人在年龄、手术时间、手术种类均无显著差异（P〉0．05）。恶心、呕吐等副作用发生率KF组低于MF组（P〈0．05）。镇痛满意度KF较高于MF组。结论：综合比较，氯胺酮复合芬太尼组优于吗啡复合芬太尼组，有较好的临床应用价值。Objective： To compare ketamine combining fentanyl （KF） with morphine combining fentanyl （MF） for postoperative intravenous analgesia. Methods： 80 operative patients with gynecological disease （ASA Ⅰ～Ⅱ）, anesthetized with continuous epidural anesthesia, were randomly allocated to receive either KF （40 patients） or MF （40 patients）. Vital signs, VAS, rate of pleased analgesia and side effect were recorded for 48 hours after intravenous analgesia. Resuhs： Compared with MF, KF showed higher rate of pleased analgesia （ P 〈 0.05）, and lower rate of side effect, for example, vomit and nausea （ P 〈 0.05）. Conclu- sion： KF is a safe and effective method of postopereative intravenous analgesia, and superior to MF in practice.

关 键 词：氯胺酮 芬太尼 吗啡 镇痛 

分 类 号：R614[医药卫生—麻醉学]