醋酸地塞米松固体脂质纳米粒冻干粉针的体外释放研究  

Release characteristics of dexamethasone acetate solid lipid nanoparticles lyophilized power in vitro

作　　者：简炎林[1] 邹国芳[1] 嵇大伟[2] 黄园[2] 

机构地区：[1]深圳市第二人民医院,广东深圳518035 [2]四川大学华西药学院,四川成都610041

出　　处：《中国医院药学杂志》2009年第12期997-999,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究醋酸地塞米松固体脂质纳米粒冻干粉针的体外释放规律。方法:选用0.1mol·L-1磷酸盐缓冲液(pH7.4)作为释药介质,测定并绘制其体外释放曲线,并对释药数据进行模型拟合。结果:醋酸地塞米松固体脂质纳米粒冻干粉针在0,4,12,48,168h的累计释药百分率分别为56.82%,71.67%,73.10%,85.40%;最佳拟合模型为Peppas方程。结论:醋酸地塞米松固体脂质纳米粒冻干粉针的体外释放具有突释和缓释效应。ORIECTIVE To study the release characteristics of dexamethasone acetate solid lipid nanoparticle lyophilized power in vitro. METHODS Phosphate buffer（0. 1mol·L^-1, pH 7. 4） was chosen as the release medium. The in vitro release characteristics of the nanoparticles were investigated and simulated by regression equation. RESULTS The accumulation release of the drug from nanopartieles in 0, 4, 12, 48, 168 h were 56. 82 %, 71.67%, 73. 10 %, 85.40%, 90. 81%, respectively. The data was best fitted with Peppas formula. CDNCLUSION Both burst-release effect and sustained-release effect are the release characteristics of dexamethasone acetate solid lipid nanoparticles lyophilized power in vitro.

关 键 词：醋酸地塞米松 固体脂质纳米粒 体外释放 

分 类 号：R944[医药卫生—药剂学]