姜黄素对大鼠早期肝缺血再灌注损伤肺的保护作用  

Protective effects of curcumin on lung injury in the liver early ischemia/reperfusion in rats

作　　者：向进见[1] 田夫[1] 李明忠[1] 蒋雪峰[1] 邓清[1] 沈世强[2] 童仕伦[2] 程本静[1] 

机构地区：[1]长江大学附属第一医院普通外科,湖北荆州434000 [2]武汉大学人民医院普外科

出　　处：《中国医师杂志》2009年第6期763-766,共4页Journal of Chinese Physician

摘　　要：目的探讨姜黄素对大鼠肝脏缺血再灌注早期损伤（再灌注1、3h）肺的保护作用。方法将大鼠随机分为假手术组（A组）、对照组（B组）和实验组（c组）。通过检测再灌注早期肺组织病理学的改变及肺组织中SOD、CAT、MDA、MPO的含量来评价姜黄素对大鼠肝脏缺血再灌注损伤肺的保护作用。结果姜黄素可减少大鼠肝缺血再灌注损伤肺间隔的水肿和肺泡中红细胞和白细胞的渗出。姜黄素提高了早期缺血再灌注后肺组织中SOD、CAT含量，降低了肺组织中MDA、MPO含量。结论姜黄素通过抑制肺组织中的氧自由基的生成及中性粒细胞的浸润，从而在早期大鼠肝缺血再灌注损伤中起到了对肺的保护。Objective To explore protective effects of curcumin on lung injury in the early hepatic ischemia/reperfusion （reperfusion for 1 and 3 hour） in rats. Methods Wistar rats were randomly divided into the following groups： Group A （ sham operation） , group B （control group） and group C （curcumin applied）. Contents of superoxide dismutase （SOD）, catalase （CAT）, malondialdehyde （MDA）, myeloperoxidase （MPO） in lung tissues were determined to evaluate the protective effect of curcumin on lung injury in the injury of ischemia/reperfusion. Results Curcumin relieved edema of diaphragmatic wall and exudation of blood cell and white cell in pulmonary alveoli. Curcumin increased the contents of SOD, CAT and decreased contents of MDA, MPO in lung tissue. Conclusion By repressing the generation of oxygen free radical and infiltration of polymorphonuclear leukocyte in lung tissue, curcumin can relieve lung injury in the early hepatic ischemia/reperfusion.

关 键 词：姜黄素/药理学 再灌注损伤/预防和控制 肝疾病/药物疗法 肺/药物作用 

分 类 号：R285.5[医药卫生—中药学]