红葱萃取物对离体大鼠主动脉血管环的影响研究  

Effect of Eleutherine Americana Extracts on Rats' Vascular Ring of Aorta ex Vivo

作　　者：刘西京[1,2] 汪程远[3] 王乃利[1,2] 李荣先[1,2] 

机构地区：[1]深圳清华大学研究院,深圳市518057 [2]深圳中药及天然药物研究中心,深圳市518057 [3]重庆工商大学药物化学与化学生物学研究中心,重庆市400067

出　　处：《中国药房》2009年第18期1376-1378,共3页China Pharmacy

摘　　要：目的:研究红葱萃取物(氯仿和乙酸乙酯萃取物)对离体大鼠胸主动脉血管环的影响作用。方法:将大鼠分为3组,即空白和氯仿、乙酸乙酯萃取物组,用Powerlab生物信号采集与分析系统测定离体主动脉血管环张力的变化。结果:与空白组比较,氯仿和乙酸乙酯萃取物组的血管环明显舒张,对苯肾上腺素(PE)和KCl引发的预收缩有显著抑制作用(P<0.05或P<0.01)。氯仿部位较乙酸乙酯部位萃取效果好(P<0.05或P<0.01)。结论:红葱的氯仿和乙酸乙酯萃取部位既能直接舒张血管环,亦能抑制PE和KCl对血管环的预收缩作用。OBJECTIVE： To study the effects of Eleutherine americana extracts （chloroform and acetic ether extracts） on isolated rats＇ vascular ring of thoracic aorta. METHODS： The rats were assigned to one of the following 3 groups： blank group, chloroform extract group and ethyl acetate extract group. Tensions of the vascular rings were measured with Powerlab biological signal analytical system. RESULTS： As compare with blank, the vascular rings were significantly relaxed in chlo- roform extract- treated and ethyl acetate extract- treated groups, suggesting the marked inhibitory effects of the chloroform extract and the ethyl acetate extract of Eleutherine americana on the pre - contraction of the vascular rings induced by phenylephrine（PE） and KC1 （P〈0.05 or P〈0.01） . The extraction efficacy of chloroform extract was better than that of ethyl acetate extract（P 〈 0.05 or P 〈 0.01） .CONCLUSION ： The chloroform extract and the ethyl acetate extract of Eleutherine americana can directly dilate vascular rings and inhibit the pre - contraction of the vascular rings induced by phenytephrine （PE） and KC1.

关 键 词：红葱 胸主动脉 大鼠 

分 类 号：R285[医药卫生—中药学] R932[医药卫生—中医学]