姜黄素固体脂质纳米粒制备工艺研究  

Preparation Technology of Curcumine Solid Lipid Nanoparticles

作　　者：宋金春[1] 邓睿园[2] 夏亚子[2] 吕桦[2] 

机构地区：[1]武汉大学人民医院药学部,武汉市430060 [2]武汉大学药学院,武汉市430072

出　　处：《中国药房》2009年第18期1383-1385,共3页China Pharmacy

基　　金：国家重点基础研究发展计划(973计划)课题(2009CB930301)

摘　　要：目的:制备姜黄素固体脂质纳米粒(Cur-SLN)。方法:用乳化蒸发-低温固化技术制备Cur-SLN,以姜黄素、泊洛沙姆188、山嵛酸甘油酯、卵磷脂用量为考察因素,以包封率为指标,用正交试验优选处方,并考察其形态、粒径、表面电位、包封率、体外释药特性。结果:优选出姜黄素、泊洛沙姆、山嵛酸甘油酯、卵磷脂的用量分别为8、320、140、320mg,所制得的脂质纳米粒为类圆球状,粒径为(134±5)nm,包封率为(67.4±1.3)%,平均表面电位值为(-23.5±1.5)mV,药物体外释放符合Higuchi方程。结论:采用乳化蒸发-低温固化技术制备Cur-SLN可行,可为开发姜黄素新型注射剂提供试验依据。OBJECTIVE： To prepare Curcumine solid lipid nanoparticles （Cur-SLN） .METHODS： Cur-SLN was prepared by emulsification evaporation - solidification at low temperature. The formulation of Cur - SLN was optimized by orthogonal experiment with the contents of curcumine, poloxamer 188, docosanoic acid glyceride lecithin used as factors and with entrapment efficiency as index; meanwhile, the appearance, particle size, surface potential, entrapment efficiency and the release profile of cureumine in vitro were studied. RESULTS： The optimized preparation conditions were as follows： the contents of curcumine, poloxamer, docosanoic acid glyceride lecithin were 8 mg,320 mg, 140 mg and 320 mg, respectively. The Cur- SLN assumed spherical shape with particle size at （134±5） nm, entrapment efficiency at （67.4±1.3）% and mean surface potential at（ -23.5±1.5） inV. The release profile of curcumine in vitro fitted Higuchi equation. CONCLUSION： It is feasible to prepare Cur- SLN by emulsion evaporation- solidification at low temperature, and the study results serve as experimental evidence for developing new curcumine injection.

关 键 词：姜黄素 固体脂质纳米粒 乳化蒸发-低温固化技术 

分 类 号：R283.62[医药卫生—中药学] R943[医药卫生—中医学]