正交试验优选消郁安神胶囊中挥发油包合工艺  

Optimization of the Inclusion Process of Essential Oil in Xiaoyu Anshen Capsules

作　　者：秦剑[1] 李卿[1] 肖铭玉[1] 张莉[1] 蒋渝[1] 

机构地区：[1]重庆市中药研究院,重庆市400065

出　　处：《中国药房》2009年第18期1386-1387,共2页China Pharmacy

基　　金：重庆市自然科学基金资助项目(2008BA5009)

摘　　要：目的:优选消郁安神胶囊中广藿香、石菖蒲挥发油包合的最佳工艺。方法:采用饱和水溶液法进行包合,以挥发油包合率和收得率为指标,以β-环糊精(CD)与挥发油的比例、包合温度、包合时间为考察因素,采用正交试验优选包合工艺,并对包合物的物相进行差示扫描量热(DSC)测定。结果:优选的包合工艺为水∶β-CD=10∶1,50℃搅拌1h,挥发油包合率达90%。DSC图谱显示,包合物已形成新的物相。结论:优选的包合工艺可制得稳定的分子间包合物,且挥发油包合率高。OBJECTIVE：To optimize the inclusion process of the volatile oil of Pogostemon cablin and Acorus tatarinowii in Xiaoyu anshen capsule. METHODS： The inclusion process was carried out by saturated water solution method. And the inclusion process was optimized by orthogonal experiment with the inclusion ratio and yield of the volatile oil as indexes taking the ratio of volatile oil to β - CD, the temperature and the time of inclusion as factors. The physical phase of the inclusion complex was detected by differential scanning calorimetry（DSC） .RESULTS： The optimum inclusion process was established as follows： the ratio of oil to β-CD = 1 ： 8; the ratio of water to β- CD = 10 ： 1; the inclusion time was lh and the inclusion temperature was 50℃ .The inclusion rate was as high as 90%. The DSC revealed that a new physical phase has been formed for the inclusion complex. CONCLUSION： The intermolecular inclusion complex with good stability and high yield of volatile oil could be obtained from the optimized inclusion process.

关 键 词：广藿香 石菖蒲 挥发油包合 消郁安神胶囊 

分 类 号：R283.65[医药卫生—中药学] R284.2[医药卫生—中医学]