丹芪通片质量标准研究  

Quality Standard of Danqitong Tablets

作　　者：吴晓松[1] 何晓敏[1] 赵文[2] 廖婉莹[2] 

机构地区：[1]暨南大学附属第一医院,广州市510630 [2]暨南大学药学院,广州市510632

出　　处：《中国药房》2009年第18期1407-1409,共3页China Pharmacy

摘　　要：目的:建立丹芪通片的质量标准。方法:采用薄层色谱(TLC)法鉴别方中丹参、黄芪;采用可见-紫外分光光度法和高效液相色谱法分别测定方中总皂苷和丹参酮ⅡA的含量。结果:丹参、黄芪的TLC斑点清晰、分离度好。总皂苷、丹参酮ⅡA的检测浓度分别在0.056～0.12mg.mL-1(r=0.9993)、0.002019～0.03213mg.mL-1(r=0.9999)范围内与各自峰面积积分值呈良好线性关系;平均回收率分别为97.61%、95.74%,RSD分别为2.10%、1.93%。结论:所建标准可用于丹芪通片的质量控制。OBJECTIVE： To establish the quality standard of Danqitong tablets.METHODS：Salvia miltiorrhiza and Radix Astragali in the formulation were identified qualitatively by TLC, and the contents of total saponins and tanshinone-ⅡA in the tablets were determined by visible ultraviolet spectrophotometry and HPLC, respectively.RESULTS： The TLC spots of Salvia miltiorrhiza and Radix Astragali were clear and well -separated. The linear ranges of total saponins and tanshinone - ⅡA were 0.056-0.12 mg · mL^-1（ r = 0.999 3） and 0.002 019-0.032 13 mg·mL^-1（r = 0.999 9）, respectively, and the average recovery rates were 97.61% （RSD = 2.10% ） and 95.74% （RSD = 1.93 % ）, respectively. CONCLUSION ： The established standard is applicable for the quality control of Danqitong tablets.

关 键 词：丹芪通片 丹参 黄芪 丹参酮ⅡA 总皂苷 高效液相色谱法 可见紫外分光光度法 

分 类 号：R283.64[医药卫生—中药学] R927.1[医药卫生—中医学]