Effects of hormone replacement therapy on magnetic resonance imaging of brain parenchyma hyperintensities in postmenopausal women  

作　　者：Yan-yong LIU Ling HU Chao JI Dong-wen CHEN Xi SHEN Nan YANG Yun YUE Jing-mei JIANG Xia HONG Qin-sheng GE Ping-ping ZUO 

机构地区：[1]Department of Pharmacology, School of Basic Medicine, Peking Union Medical College and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China [2]Peking Union Medical College Hospital, Beijing 100730, China

出　　处：《Acta Pharmacologica Sinica》2009年第7期1065-1070,共6页中国药理学报（英文版）

摘　　要：Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women. Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain. Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed. Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.Aim： To apply 3.0 magnetic resonance imaging （MRI） to study the effects of long-term, low dose hormone replacement therapy （HRT） on the brain parenchyma of postmenopausal women. Methods： A total of 155 postmenopausal healthy female medical staff members from Peking Union Medical College Hospital were enrolled. The HRT group was composed of 71 subjects who had been given a low dose of HRT for over 4 years, while 84 women who had never been given HRT were enrolled in the control group. The Mini-Mental State Examination （MMSE） was used to evaluate menta state, and an Enzyme-Linked ImmunoSorbent Assay （ELISA） was used to detect plasma levels of sex hormones. In addition, all participants were subjected to an MRI, including axial T2 weighted imaging （T2WI）, fluid-attenuated inversion recovery （FLAIR）, T1 weighted imaging （T1WI, oblique coronal, vertical to the hippocampus, slice thickness 3 mm without gaps）, and a 3D image of the whole brain. Results： The ELISA showed that the plasma level of estradiol in the HRT group was significantly higher than that in the control group （P〈0.05）. No differences were observed in the MMSE between the two groups. In participants older than 70 years of age, the number of deep white matter hyperintensities （DWMHs） in the control group was significantly higher than that in the HRT group （P=0.0013）; however, in other age subgroups, no statistical differences were observed. Finally, no significant difference in periventricular hyperintensity （PVH） between the two groups was observed. Conclusion： We found that a high plasma level of estradiol in postmenopausal women receiving long-term HRT was correlated with the survival of brain parenchyma.

关 键 词：postmenopausal women hormone replacement therapy ESTROGEN magnetic resonance imaging deep white matter hyperintensity 

分 类 号：Q753[生物学—分子生物学] O482.531[理学—固体物理]