缬草抗心律失常活性部位的筛选  

Screening of Active Site of the Extracts of Valeriana Officinalis L.on Cardiac Arrhythmias

作　　者：段雪云[1,2] 方颖[1] 龚占峰[1] 周颖[1] 刘焱文[1] 

机构地区：[1]湖北中医学院"中药资源与中药复方"省部共建教育部重点实验室,武汉430061 [2]湖北省中医院

出　　处：《中国药师》2009年第7期842-844,共3页China Pharmacist

基　　金：国家自然科学基金项目(编号:30500053)

摘　　要：目的:筛选缬草抗心律失常的活性部位。方法:建立以氯仿诱导心律失常的小鼠模型,分别灌胃给予缬草不同的提取部位,以小鼠室颤发生率为观察指标。结果:缬草提取物中水液部位和缬草油部位分别在5 g(生药)·ml^(-1)和2.5 g(生药)·ml^(-1)能显著降低氯仿所致小鼠室颤发生率,且水液部位的90%乙醇洗脱物和水洗脱物能显著降低氯仿所致小鼠室颤发生率(P<0.05)。结论:缬草提取物中水液部位和缬草油有抗心律失常作用。Objective： To study the antiarrhythmic effects of extracts of Valeriana offwinalis L. Method： The arrhythmic animal models were caused by trichloromethane. The groups were treated respectively with the extracts of Valeriana officinalis L. and the incidence ratios of ventricular fibrillation （VF） was observed. Result： Water-extracts and essential oil of Valeriana officinalis L. in 5 and 2.5 g·ml^-1 （crude drug） could markedly decreased the ratio of VF caused by trichloromethane in mice, the 90% alcohol eluate and water eluate in water-extract could markedly do so. Conclusion： The water-extract and essential oil of Valeriana officinalis L. are more effective on cardiac arrhythmias.

关 键 词：缬草 缬草提取物 室性纤颤 抗心律失常 

分 类 号：R285.5[医药卫生—中药学]