夜热清颗粒中丹皮酚的稳定性研究  

Study on the Stability of Paeonol in Ye Re Qing Granules

作　　者：张蜀[1] 邓红[1] 谢小燕[1] 林华庆[1] 余楚钦[1] 

机构地区：[1]广东药学院药物研究所.广东省药物新剂型重点实验室,广东广州510006

出　　处：《时珍国医国药》2009年第6期1365-1367,共3页Lishizhen Medicine and Materia Medica Research

基　　金：广东省科技计划项目(No.2005A30101012);广东省中医药局科技项目(No.1050046)

摘　　要：目的研究提高夜热清颗粒中丹皮酚稳定性的处方工艺。方法采用饱和水溶液法将丹皮酚制成β-环糊精包合物,并用正交实验法进行处方工艺筛选。结果筛选出丹皮酚最佳包合工艺是:丹皮酚与β-环糊精的比例为1∶12,包合温度为50℃,包合时间为1.0 h。结论制成β-环糊精包合物后夜热清颗粒中丹皮酚的稳定性得到较大提高。Objective To study the preparation and processing technology in order to improve the stability ot paeonol in Ye Be Qing Granules. Methods The paeonol - β - CD complex was prepared using a saturated solution method and orthogonal method was used to screen the technological process. Results The optimum inclusion condition of paeonol was paeonol ： β-CD in proportion as 1： 12, keeping temperature at 50 ℃ for 1.0 h. Conclusion The stability of paeonol in YeReQing granules can be significantly improved after being made to paeonol -β-CD complex .

关 键 词：夜热清颗粒 丹皮酚 Β-环糊精包合物 饱和水溶液法 稳定性 

分 类 号：R283[医药卫生—中药学]