卡介苗加脂多糖诱发小鼠免疫性肝损伤模型的研究  

An Investigation on Bacillus Calmette-Guerin and Lipopolysaccharide Inducing the Model of Immunity Injury of Liver in Mice

作　　者：魏艳丽[1] 杜洪建[1] 金志华[1] 林益平[1] 吴美玲[1] 

机构地区：[1]金华职业技术学院,浙江金华321007

出　　处：《金华职业技术学院学报》2009年第3期69-71,共3页Journal of Jinhua Polytechnic

摘　　要：小鼠免疫性肝损伤模型较接近于人类肝炎发病机制,对其进行研究具有重要意义。不同剂量的卡介苗(BCG)和脂多糖(LPS)以一定时间间隔相继静脉注射会引起不同程度的肝损伤。实验结果发现BCG1mg/只+LPS8ug/只相隔12天注射,肝损伤较其它组明显,BCG加LPS诱导的肝损伤模型是一种较新的模型。既可用于从免疫途径筛选新药,亦可用于免疫与肝细胞损伤机理的研究。Rat model of immuno-hepatic damage is similar to the pathogenesis of human hepatisis. Tail-vein injection with different dosage BCG and LPS can cause rat injury of liver to some degree. Several rat models are tested in this experiment. Results： lmg BCG injection per rat and 8ug LPS after 12 days have a better effect. The model induced by BCG and LPS may be used as a new one, not only selecting new drug from immuno-path, but also speculating pathogenesis between immunity and hapatoeyte injury.

关 键 词：卡介苗 脂多糖 肝损伤 丙氨酸转氨酶 

分 类 号：R965[医药卫生—药理学]