胺碘酮和普罗帕酮治疗老年阵发性室上性心动过速效果及安全性比较  

Safe Administration and Efficacy of Amiodarone and Propafenone in Elerly Patiens with Paroxysmal Supraventricular Tachycardia

作　　者：胡鹏里[1] 唐文明[1] 陈鹏[1] 

机构地区：[1]福建医科大学附属厦门市第一医院杏林分院急诊科,福建厦门361022

出　　处：《华北国防医药》2009年第3期20-21,共2页Medical Journal of Beijing Military Region

摘　　要：目的:观察静脉注射胺碘酮和普罗帕酮治疗老年人阵发性室上性心动过速(PSVT)的疗效及安全性,为临床治疗老年PS-VT选择用药提供依据。方法:将60例老年PSVT随机分为两组,胺碘酮组32例,普罗帕酮组28例。分别给予胺碘酮、普罗帕酮静脉注射治疗,观察效果及不良事件发生情况。结果:胺碘酮组和普罗帕酮组有效率分别为87.50%和78.57%,两组相比差异无统计学意义(P>0.05);用药后胺碘酮的复律时间为(18.24±3.08)min,普罗帕酮的复律时间为(8.50±1.73)min,两组差异有统计学意义(P<0.05);两组不良反应发生率差异无统计学意义(21.88%vs28.57%,P>0.05)。结论:胺碘酮和普罗帕酮均可作为老年人PSVT复律治疗的一线治疗用药,疗效确切、安全。Objective：To observe the effect and safety of intravenous Amiodarone and Pmpafenone in treating elderly patients with paroxysmal supraventricular tachycardia（PSVT）. Methods：60 patients of PSVT were randomly divided into two groups; intravenous Amiodarone group （n = 32） and intravenous Pmpofenone group（ n = 28）. Efficacy and adverse effect were observed. Results：The termination rate of PSVT was 87.50% in Amiodarone group and 78.57% in Pmpafenone group,showing no significant difference （P 〉 0. 05）. The time of heart beat recovery in Amiodarone group were （ 18.24 ± 3.08 ） rain. and （ 8.50 ± 1.73 ） rain. in Propafenone-group with difference of sitatistical significance（P 〈 0.05 ）. The incidence rates of side effect were 21.88% and 28.57% respectively with significant difference（ P 〉 0.05 ）. Conclusion：Administration of Amiodarone and Pmpafenone is efficient were safe in the treatment of PSVT.

关 键 词：胺碘酮 普罗帕酮 心动过速 阵发性 心动过速 室上性 老年人 

分 类 号：R972.2[医药卫生—药品] R541.71[医药卫生—药学]