适量运动提高慢性疲劳综合症小鼠脾细胞IL-2含量  

Appropriate Exercises Enhanced Spleen IL-2 Contents of Mice with Chronic Fatigue Syndrome

作　　者：曾白琳[1] 孙雄华[1] 唐双阳[2] 黄祁平[2] 万艳平[2] 

机构地区：[1]湖南环境生物职业技术学院体育部,湖南衡阳421005 [2]南华大学医学院,湖南衡阳421001

出　　处：《湖南环境生物职业技术学院学报》2009年第2期13-15,共3页JOurnal of Hunan Environment Biological Polytechnic

基　　金：湖南环境生物职业技术学院院长基金资助(编号:Z07-03);衡阳市科研资助(编号:2008KJ019)

摘　　要：观察运动量对慢性疲劳综合症(CFS)小鼠脾脏指数及脾细胞IL-2水平的影响,为CFS运动处方的研究奠定实验基础.方法:将40只小鼠随机地分成4组,即Ⅰ组(正常对照组)、Ⅱ组(CFS对照组)、Ⅲ组(CFS运动1组)、Ⅳ组(CFS运动2组),每组10只.通过立竭性游泳建立CFS小鼠模型,观察不同强度运动后,计算脾脏指数,ELISA检测小鼠脾细胞IL-2含量.Ⅱ组、Ⅲ组、Ⅳ组脾脏指数明显高于Ⅰ组(P<0.05),且Ⅲ组、Ⅳ组脾脏指数明显低于Ⅱ组(P<0.05);Ⅳ组脾细胞IL-2诱生量明显高于Ⅱ组(P<0.05).适量运动能明显改善CFS小鼠脾脏指数并促进其脾细胞分泌IL-2.表2,参7.To provide the experimental basis for studying exercises prescription to mice with chronic fatigue syndrome （ CFS）, and to observe the effects of exercises on spleen index and IL - 2 level of murine models with CFS. Forty mice were randomly divided four groups as GroupⅠ （comparative normal group, 10 mice）, Group Ⅱ （ comparative CFS group, 10 mice ）, Group Ⅲ（ exercise 1 group, 10 mice ）, Group Ⅳ （ exercise 2 group, 10 mice）. The murine models with CFS were built by exhaustive swimming. The spleen index were detected and the contents of splenic IL - 2 were determined by ELISA after murine models exercised by two kinds of intensity. The spleen index of Group Ⅱ, Ⅲand Ⅳ was obvious higher than that of Group Ⅰ （P 〈 0.05）, resprectively. Group Ⅲand Ⅳ were significantly low, and there was obvious difference by compared with Group Ⅱ（ P 〈 0.05 ）. The contents of splenic IL - 2 in murine models with exercise training twice everyday were significantly increased by compared with Group Ⅱ（P 〈 0.05 ）, but not Group Ⅲ. The spleen index of mice with CSF could be improved and IL-2 secretion was raised after appropriate exercises. 2tabs. ,7refs.

关 键 词：运动 慢性疲劳综合症(CFS) 脾 IL-2 

分 类 号：R446[医药卫生—诊断学]