早期使用超微量肝素治疗新生儿DIC倾向疗效观察  

Curative Effects of Early Ultramicro Heparin Application on DIC Tendencies in Newborns

作　　者：袁华敏 樊秋民 林祥副 

机构地区：[1]广东省韶关市妇幼保健院儿科,512000

出　　处：《中华全科医学》2009年第7期702-703,共2页Chinese Journal of General Practice

基　　金：广东省韶关市医药卫生科研计划项目[WSTJJ20071105362123196310152431(Y08062)]

摘　　要：目的观察早期皮下注射超微量肝素对胎盘性产前出血新生儿和孕母外伤早产儿疗效。方法将54例胎盘性产前出血新生儿和孕母外伤早产儿有DIC倾向者随机分为A、B、C三组,分别是应用超微量肝素组、普通剂量肝素组及不用肝素组进行治疗。观察三组TT、APTT、PT、Fib、PLT及D-二聚体等出凝血指标和治愈率。结果A组用药24 h后与用药前比较PT缩短、Fib升高、PLT无明显变化及D-二聚体降低,48 h后PT、APTT、TT与用药前比较均缩短、Fib升高及D-二聚体降低。B组用药24 h后PT较用药前延长,APTT、TT、Fib及D-二聚体无明显改变,用药48 h后PT、TT均延长,与用药前比较差异有显著性。C组用药24 h后PT较用药前延长,APTT、TT、Fib及D-二聚体无明显改变,用药48 h后PT、TT均延长,与用药前比较差异有显著性。三者治愈率比较有显著性差异,A组治愈率最高。结论早期皮下注射超微量肝素对胎盘性产前出血新生儿和孕母外伤早产儿有疗效。Objective To observe and test the curative effects of ultramicro heparin injected subcutaneously on the newborns of prenatal placental hemorrhage and premature infants caused by maternal injury. Methods 54 cases of those kinds of newborns and premature infants who had a tendency of DIC were randomly divided into group A,B and C. The group A was treated with ultramicro dose of heparin, group B with ordinary dose and group C without injecting heparin. The changes of TT, APTT PT, Fib, PLT, D dimer and other indicators of bleeding and clotting were observed and the curative rate of different groups were compared. Results In group A, PT were shortened, Fib increased, D dimer declined and PLT had no clear change 24 hours later after medication as compared with premedication, and 48 hours later, all PT, APTT and Tr were shorted, Fib increased, D dimer declined respectively. In group B, PT became longer, APTr, TT, Fib and D dimer were no clear change 24 hours later after medication as compared with premedication;48 hours later, both PT and TT were prolonged, and these changes were obvious. The results in group C were same as in group B. However, the cure rate of group A was highest and the difference of three groups was significantly. Conclusion It is helpful for newborn of prenatal placental hemorrhage and premature infants caused by maternal injury to inject subcutaneously ultramicro heparin early.

关 键 词：超微量肝素 DIC倾向 胎盘性产前出血 新生儿 

分 类 号：R973.2[医药卫生—药品] R554.8[医药卫生—药学]