年龄对C57BL/6小鼠在辐射状六臂水迷宫中表现的影响  

Effect of Aging on the Performance of the Radial Six-arm Water Maze Task in C57BL/6 Mice

作　　者：熊向东[1] 陈贵海[2] 

机构地区：[1]安徽省六安市人民医院,237005 [2]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《医学研究杂志》2009年第7期64-67,共4页Journal of Medical Research

基　　金：安徽省自然科学基金(03043708)

摘　　要：目的探讨C57BL/6小鼠在辐射状六臂水迷宫RAWM中是否有学习记忆能力减退。方法用RAWM实验测空间性学习记忆能力。结果老年小鼠空间性学习记忆能力下降。结论RAWM是优秀空间学习记忆任务,对检测C57BL/6小鼠年龄相关性学习记忆能力减退敏感。Objective To explore whether there is the decline of learning and memory ability in C57BL/6 mice in radial six - arm water maze （RAWM） task. Methods The RAWM task was used to test the spatial abilities of learning and memory. Results All of old mice showed the decline of spatial learning and memory ability in the RAWM task. Conclusion RAWM task is excellent spatial learning and memory task and is sensitive to measure the age - related decline of learning and memory ability in C57BL/6 mice.

关 键 词：行为 记忆 小鼠 衰老 

分 类 号：R378.2[医药卫生—病原生物学] R774.5[医药卫生—基础医学]