脓毒症过程中树突状细胞的研究进展  

Progress in researches on the role of dendritic cells during sepsis

作　　者：相小松[1] 李宁[1] 李秋荣[1] 赵允召[1] 黎介寿[1] 

机构地区：[1]南京军区南京总医院解放军普通外科研究所,江苏南京210002

出　　处：《医学研究生学报》2009年第6期651-654,共4页Journal of Medical Postgraduates

基　　金：国家重点基础研究发展计划"973"课题基金资助项目(批准号:2007CB513005)

摘　　要：脓毒症是造成外科重症病人死亡的主要原因。近年来的研究显示脓毒症过程中机体免疫功能的损害与树突状细胞(DC)的变化有密切关系。脓毒症过程中DC大量丢失,生成的细胞因子也发生变化,并影响患者的预后。因此,对DC的研究有助于更好地诊断和治疗脓毒症。文章就近年来脓毒症过程中DC的研究进展作一综述。Sepsis is the leading cause of mortality in critically ill patients. Studies indicate that immune suppression in sepsis is more often associated with poor outcome. Dendritic cells may contribute largely to the development of immune suppression during sepsis. This article reviews the emerging data indicating the key role of dendritic cells in sepsis induced immune suppression. A deeper insight into the dendritic cell changes during sepsis may provide a powerful weapon against sepsis.

关 键 词：脓毒症 树突状细胞 免疫功能损害 

分 类 号：R631.2[医药卫生—外科学]