复方苦参结肠溶胶囊对溃疡性结肠炎患者结肠黏膜IκB-α表达的作用  

Effect of Compound Recipe Lightyellow Sophora Root Caps on Proteins Expression of IκB-α in Colonic Mucosa of People with Ulcerative Colitis

作　　者：范恒[1] 庄雄[1] 段雪云[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,武汉430022 [2]湖北中医学院附属医院药剂科,武汉430061

出　　处：《中西医结合研究》2009年第3期113-116,共4页Research of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金项目(No.30772878)

摘　　要：目的观察复方苦参结肠溶胶囊对溃疡性结肠炎(UC)患者(湿热内蕴证)结肠黏膜IκB-α蛋白表达的作用,并对其作用机制进行初步探讨。方法经结肠镜及病理证实的24例UC患者,随机分为中药组(16例)和西药组(8例),中药组用复方苦参结肠溶胶囊治疗,西药组用美沙拉嗪治疗,共治疗8周。采用免疫组化法检测两组治疗前后IκB-α蛋白的阳性细胞表达率。结果治疗前全部结肠黏膜IκB-α蛋白阳性细胞表达率明显高于治疗后(P<0.01),治疗后复方苦参结肠溶胶囊组结肠黏膜IκB-α蛋白阳性细胞表达率与西药组差异无统计学意义(P>0.05)。结论复方苦参结肠溶胶囊组使UC患者结肠黏膜IκB-α蛋白阳性细胞表达率明显降低,这可能是其治疗UC的作用机制之一。Objective To study the effect of compound recipe lightyellow sophora root caps（LSRC）on the expression of IκB-α in colonic mucosa of patients with ulcerative colitis（damp-heat brewing internally）, and to explore the therapeutic mechanism. Methods 24 patients with ulcerative colitis who were diagnosed by colonoscope and biopsy were randomly divided into two groups as follows： the TCM group and the western medicine group. 16 patients in the TCM group were treated with LSRC for 8 weeks,and 8 patients in the western medicine group were treated with mesalazine for 8 weeks. The positive expression rate of IκB-α was measured by immunohistochemical method. Results The positive expression rate of IκB-α in two groups decreased significantly after treatment（P〈 0.01） ,but the difference between two groups was no significant （P〉 0.05）. Conclusion One of the therapeutic mechanism of LSRC may attribute to its inhibiting the positive rate of IκB-α in colonic mucosa of patients with ulcerative colitis.

关 键 词：复方苦参结肠溶胶囊 美沙拉嗪 溃疡性结肠炎 IΚB-Α 

分 类 号：R259[医药卫生—中西医结合]