肾康颗粒治疗慢性肾小球肾炎的主要药效学研究  

Pharmacodynamic study of therapeutic effects of Shenkang Particles on chronic glomerulo-nephritis

作　　者：岳南[1] 只德广[1] 赵益桂[1] 苏雅[1] 

机构地区：[1]天津药物研究院新药评价中心,天津300193

出　　处：《现代药物与临床》2009年第3期155-159,共5页Drugs & Clinic

摘　　要：目的观察肾康颗粒对慢性肾小球肾炎的治疗作用。方法采用家兔C-BSA肾炎、大鼠Heymann肾炎、大鼠高黏滞血症及大鼠利尿等实验模型,观察、测定相应的实验指标。结果肾康颗粒明显降低24h尿蛋白的量、血清肌酐及尿素氮水平;抑制肾小球直径和肾小球细胞数的增加;抑制高分子右旋糖酐所致大鼠全血黏度及血浆比黏度的升高;具有明显的利尿作用。结论肾康颗粒对动物慢性肾炎有明显的治疗作用。Objective To evaluate the therapeutic effects of Shenkang Particles on chronic glomerulo- nephritis. Methods C-BSA induced nephritis in rabbits, tteymann nephritis in rats, hyperviscosity in rats, and diuretic test in rats were used to investigate the effect of Shenkang Particles on the experimental indicators. Results Shenkang Particles could significantly decrease urinary protein in 24 h, serum creatinine and blood urea nitrogen, and inhibited the increasing of diameter and cells of glomerulus, increasing of whole blood viscosity and plasma viscosity induced by high molecular dextran. Shenkang Particles showed also diuretic effect significantly. Conclusion with chronic nephritis.

关 键 词：肾康颗粒 C-BSA肾炎 HEYMANN肾炎 高黏滞血症 利尿 

分 类 号：R277.523.1[医药卫生—中医学] R286.0