液压脑损伤大鼠行为学和脑电图的研究  

Study on electroencephalogram and ethology in the rat with fluid percussion brain injury

作　　者：李雪峰[1] 刘绍明[1] 郑刚[1] 窦彩绘[1] 李建[1] 

机构地区：[1]兰州军区乌鲁木齐总医院神经外利,830000

出　　处：《中华神经外科杂志》2009年第6期560-563,共4页Chinese Journal of Neurosurgery

基　　金：中国人民解放军兰州军区医药卫生科研基金资助项目（LHX～2007010）

摘　　要：目的通过液压脑损伤大鼠行为学和脑电图的研究以探讨其在外伤后癫痫中的研究价值。方法建立液压脑损伤动物模型并进行为期3个月大鼠行为学和脑电图的观察、记录。结果液压脑损伤后50只大鼠死亡19只，存活的31只中有11只出现癫痫。癫痫的发作形式主要表现为面肌痉挛、点头样运动，其次为四肢抽搐、翻转跳起等。液压脑损伤后第2个月为癫痫发生的高峰期。癫痫发作时同期脑电图可见癫痫样放电。液压脑损伤后部分非癫痫大鼠脑电图表现为1—5导联波幅增高、频率增快。结论液压脑损伤后癫痫动物模型与临床外伤后癫痫相似，与其他外伤后癫痫动物模型相比，更具有研究价值。Objective To investigate the electroencephalogram and ethology in the rat with fluid percussion brain injury and approach its research value in the post traumatic epilepsy. Methods The change of ethology and electroencephalogram of rat in the three months after fluid percussion brain injury were observed and recorded. Results Among the survival 31 rats, there were 11 rats that appeared epilepsy. Epileptic seizure manifestation principally appeared as facial spasm, nod motion, and next limbs convulsion and turnover upspring, et al. The highest epileptic incidence rate appeared in 2 months after lateral fluid percussion brain injury. There were obvious epileptic discharges on the electroencephalogram of epileptic rats and higher wave amplitude and quicker frequency on the lead of 1 -5 on the electroencephalogram of some no epileptic rats. Conclusions Post traumatic epilepsy after lateral fluid percussion brain injury in rat is similar with clinical post traumatic epilepsy. It has more research value than the other post traumatic epileptic animal model.

关 键 词：液压脑损伤 外伤后癫痫 脑电描记术 动物模型 

分 类 号：R686[医药卫生—骨科学]