Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus  

作　　者：WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei 

机构地区：[1]School of Life Sciences and Technology, Tongji University, Shanghai 200092, China [2]Shanghai Center for Bioinformation Technology, Shanghai 200235, China [3]School of Life Sciences, Fudan University, Shanghai 200433, China [4]Cancer Institute of the Second Military Medical University, Shanghai 200433, China [5]School of Life Sciences and Technology, South China University of Technology, Guangzhou 510641, China [6]National Engineering Research Center for Antibody Drugs, Shanghai 201203, China [7]Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China [8]Shanghai Municipal Center for Disease Control & Prevention, Shanghai 200336, China [9]Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (Lab of Computational Genomics, CAS-MPG Partner Institute of Computational Biology Center of Bioinformatics, Key Lab of System Biology Lab of Synthetic Biology, Institute of Plant Physiology & Ecology Institute Pasteur), Shanghai 200031, China [10]National Engineering Research Center for Biochip Technology, Shanghai Biochip Co. Ltd, Shanghai 201203, China [11]National Institute for Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China [12]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [13]Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China

出　　处：《Chinese Science Bulletin》2009年第13期2171-2173,共3页

基　　金：Supported by the National Key Basic Research and Development Program of China(Grant Nos.2004CB720103,2006AA02312);Shanghai Education Foundation(Grant Nos.000236018,2000236016)

摘　　要：In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses.In recent months, a novel influenza virus H1N1 broke out around the world. With bioinformatics technology, the 3D structure of HA protein was obtained, and the epitope residues were predicted with the method developed in our group for this novel flu virus. 58 amino acids were identified as potential epitope residues, the majority of which clustered at the surface of the globular head of HA protein. Although it is located at the similar position, the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses.

关 键 词：禽流感病毒 抗原表位 A蛋白 结构建模 和空间 生物信息学技术 三维结构 残留物 

分 类 号：Q78[生物学—分子生物学] S855.3[农业科学—临床兽医学]