强脉冲光作用下皮肤组织结构改变的实验观察及模拟  

Experimentation and Numerical Simulation of Skin Tissue Structure Irradiated by Intense Pulsed Light

作　　者：吴淑莲[1] 李晖[1] 谢树森[1] 

机构地区：[1]福建师范大学医学光电科学与技术教育部重点实验室福建省光子技术重点实验室物理与光电信息科技学院

出　　处：《激光生物学报》2009年第3期320-323,369,共5页Acta Laser Biology Sinica

基　　金：国家自然科学基金项目(60578056);教育部优秀青年教师资助计划(BD0050);福建省教育厅项目(JB07044)

摘　　要：使用强脉冲光源（IPLs）作用于小鼠皮肤上，分别用普通显微镜、双光子显微镜（TPELSM）观察、分析在IPLs作用前后及不同能量密度下皮肤组织的结构。基于pennes生物传热方程，计算光子在皮肤组织中传输所吸收的热量引起组织升温达到的温度，与实验结果相吻合。Microscopy and TPELSM were used to study the changes of mouse skin before and after irradiation with Intense pulsed light source, that is observed and analyzed the Morphologic changes of rat skin. The numerical simulation of optical energy and temperature distribution in mouse skin were carried out, which was based on pennes biology passes heat equation, and then the results were compared with that of the animal experiments, and is consistent with the experiments.

关 键 词：IPLs 双光子显微镜 数值模拟 

分 类 号：R318.51[医药卫生—生物医学工程]