掺铁TiO2纳米颗粒与恒定磁场对HL60白血病肿瘤细胞的灭活效果  

Effects of Iron-doped TiO2 Nanoparticles and Constant Magnetic Field on HL60 Leukemia Cells Activity

作　　者：廖美香[1,2] 何惠玲[2] 熊建文[2] 

机构地区：[1]中山大学物理科学与工程技术学院,广东广州510275 [2]华南师范大学物理与电信工程学院,广东广州510006

出　　处：《激光生物学报》2009年第3期324-328,共5页Acta Laser Biology Sinica

基　　金：广东省自然科学基金项目(7005845)

摘　　要：通过研究不同浓度、不同磁场作用下TiO2、掺铁TiO2纳米颗粒对HL60白血病细胞活性的影响，以及在接受光照和不接受光照条件下的细胞活性，探讨基于TiO2、掺铁TiO2纳米颗粒作为光敏剂的光动力疗法（PDT）灭活白血病肿瘤细胞的可行性。实验结果表明，纳米颗粒对细胞具有一定的抑制／毒性作用，纳米浓度越大，抑制／毒性作用越明显；磁场对细胞的毒性／抑制作用跟掺铁的浓度以及磁感应强度有关，掺铁纳米组在强磁场作用下对细胞抑制／毒性作用明显；此外，添加了纳米颗粒的PDT灭杀效率要比不添加纳米颗粒的PDT灭杀效率高。This article discussed the possibility of TiO2 and iron-doped TiO2 nanoparticles as photo sensitizer to kill tumor cells by studying the HL60 cells activity with different nanoparticles dosages, different magnetic field strength, and different conditions of receiving the visible radiation and no radiation. The experimental results showed that the nanoparticles have toxic/inhibiting effect on leukemia cells, the greater concentration of nanoparticles, the more toxic/inhibiting effect will be; while the toxic/inhibiting effect of magnetic field on cells is dependent on the concentration of iron-doped and magnetic induction intensity. The toxic/inhibiting effects to iron-doped group is obvious in the circumstance of strong magnetic field. Besides, the efficiency of PDT added nanopartieles is slightly higher than the efficiency of PDT not added nanoparticles.

关 键 词：掺铁TiO2 磁场 纳米粒 HL60细胞 

分 类 号：R318[医药卫生—生物医学工程]