布洛芬缓释凝胶的制备  

Preparation of sustained-release ibuprofen gel

作　　者：侯振伟[1] 白鹤翔[1] 张风华[1] 安雁鸣 杜晓燕[1] 

机构地区：[1]石家庄市第一医院口腔科,河北省石家庄市050011

出　　处：《中国组织工程研究与临床康复》2009年第25期4865-4867,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：2005年河北省科委指导基金项目(05276102)~~

摘　　要：目的:制备布洛芬缓释凝胶,并进行质量标准的研究及释放度测定。方法:以聚乳酸-乙醇酸共聚物(75/25)作为基质,N-甲基-2-吡咯烷酮作为溶剂,制备布洛芬缓释凝胶,以高效液相色谱法测定其含量并进行质量控制,并观察其体外释放情况。结果:布洛芬在一定浓度范围内线性关系良好,平均回收率分别为99.3%,98.6%,100.5%。体外释放度实验中,第一点(1h)累计释放率均小于30%,中间点(36h)分别为53%,52%,55%,最后点(72h)均大于80%,可见布洛芬缓释凝胶有明显的缓释作用。结论:以聚乳酸-乙醇酸共聚物(75/25)作为基质,N-甲基-2-吡咯烷酮作为溶剂,可制备出理想的布洛芬缓释凝胶,质量可靠,释放度合格。OBJECTIVE： To study the preparation, quality standard and in vitro release of sustained-release ibuprofen gel. METHODS： Sustained-release ibuprofen gel was prepared according to polylactic-co-glycolic acid （PLGA, 75/25） as base material and N-Methyl pyrrolidone （NMP） as dissolvent. In addition, a high pressure liquid chromatography （HPLC） was used to determine content, quality, and in vitro release. RESULTS： The standard curve was linear in a concentration range. The average recoveries were 99.3%, 98.6%, and 100.5%, respectively. Accumulative release rate was less than 30% at the first time point （1 hour）, 53%, 52%, and 55% at the middle time point （36 hours）, and more than 80% at the final time point （72 hours）, suggesting that sustained-release ibuprofen gel had a remarkable release effect. CONCLUSION： The materials such as PLGA 75/25 and NMP can prepare the ideal sustained-release ibuprofen gel with a standard and reliable quality and release rate.

关 键 词：布洛芬 缓释 凝胶 聚乳酸乙醇酸共聚物 

分 类 号：R318[医药卫生—生物医学工程]