K_3Fe(CN)_6-钙黄绿素体系后化学发光反应测定盐酸氯丙嗪  

A flow injection-post chemiluminescence method for the determination of chlorpromazine hydrochloride with calcein-potassium ferricyanide system

作　　者：何云华[1] 王莉平[1] 

机构地区：[1]长安大学环境科学与工程学院,西安710054

出　　处：《分析试验室》2009年第7期96-98,共3页Chinese Journal of Analysis Laboratory

摘　　要：发现了盐酸氯丙嗪在KFe（CN）6-钙黄绿素化学发光反应体系中的后化学发光反应，优化了反应条件，建立了一种利用后化学发光反应测定盐酸氯丙嗪的流动注射化学发光分析法。方法的检出限为3×10^-8g／mL。相对标准偏差为2．0％（2．0×10^-6g／mL盐酸氯丙嗪，n=11），线性范围为1．0×10^-7-1．0×10^-5g／mL。此法已用于盐酸氯丙嗪片剂中盐酸氯丙嗪含量的测定，结果与药典方法测定值一致。A post chemiluminescence （PCL） reaction was observed when chlorpromazine hydrochloride was injected into the mixture of potassium ferricyanide-calcein chemiluminescence （CL） reaction system. The experimental conditions of the CL reactions were optimized. A new chemiluminesence method for the determination of chlorpromazine hydrochloride with flow injection technique was developed. The detection limit is 3×10^-8g/mL, the relative standard deviation is 2.0% （2.0×10^-6g/mL chlorpromazine hydrochloride, n = 11）, and the liner range is 1.0×10^-7-1.0×10^-5g/mL. The method has been successfully applied to the determination of chlorpromazine hydrochloride in the chlorpromazine hydrochloride tablets, and the results are consistent with those by the method in the chinese pharmacopoeia.

关 键 词：后化学发光反应 K3Fe(CN)6 钙黄绿素 盐酸氯丙嗪 

分 类 号：O657.3[理学—分析化学]