D-二聚体在妇科术后下肢深静脉血栓形成溶栓中的意义  

Significance of D-dimer in thrombolytic therapy of lower extremity deep venous thrombosis after gynecologic operation

作　　者：韩素新[1] 陈素兰[1] 朱洁茹[1] 

机构地区：[1]华北煤炭医学院附属医院妇产科,河北唐山063000

出　　处：《华北煤炭医学院学报》2009年第4期473-474,共2页Journal of North China Coal Medical College

摘　　要：①目的探讨下肢深静脉血栓形成(DVT)的溶栓治疗过程中血浆D-二聚体的变化、疗效评价以及预后判断。②方法用胶体金免疫渗透试验(GIA)法测定26例DVT患者在溶栓治疗过程中不同时间(治疗前、治疗后第1天、第3天、1周、2周、治疗结束后)的D-二聚体含量。③结果溶栓治疗后D-二聚体水平显著性升高,峰值出现时间平均为2天。治疗后1周D-二聚体下降至溶栓前水平,治疗后2周D-二聚体与溶栓前比较差异有显著性。治疗结束后D-二聚体降至正常范围。④结论动态监测D-二聚体的水平变化可以作为DVT溶栓治疗时评价疗效及判断预后的特异性指标。Objective To investigate the change of D - dimer, curative effect evaluation and prognostic judgement in throm- bolytic therapy of lower extremity deep venous thrombolsis （DVT）. Methods Gold colloids immunofiltration assay （GIA） was used to detect D - dimer in the plasma in 26 patients with DVT at different times during thrombolytic treatment using urokinase （ before treatment, 1 day,3 days, 1 week ,2 weeks after the beginning of the treatment and in the end）. Results D -dimer levels were increased significantly after thrombolytic treatment, peak value appeared on 2nd day, while which after treatment 1 week was decreased to the levels before treatment, and there was significant difference in D - dimer between after treatment 2 weeks and before thrombolysis. D - dimer was decreased to normal levels at the end of treatment. Conclusion The change of D - dimer monitored continuously could be regarded as the special index for evaluating curative effect and judging prognosis of thrombolysis in DVT treatment.

关 键 词：下肢深静脉血栓形成 溶栓治疗 D-二聚体 

分 类 号：R713[医药卫生—妇产科学]