细胞粘附分子-1在子宫内膜异位症免疫发病机制中的研究  

Study of Intercellular adhension molecule-l in immunological pathogenesis of endometriosis

作　　者：王彤[1] 庄琳[2] 

机构地区：[1]江油市人民医院,四川江油621700 [2]四川省妇幼保健院,四川成都610036

出　　处：《四川医学》2009年第6期876-878,共3页Sichuan Medical Journal

摘　　要：目的检测子宫内膜异位症(EM)患者在位子宫内膜和异位内膜中的ICAM-1的表达,并进一步探讨ICAM-1的变化在子宫内膜异位症免疫发病机制中的意义。方法采用免疫组织化学(SP)法分别测定了EM患者在位和异位内膜及正常对照组子宫内膜中ICAM-1的表达。结果ICAM-1在子宫内膜异位症患者的异位内膜表达较在位内膜及正常对照组子宫内膜强,差异有统计学意义(P<0.05);ICAM-1在在位内膜和正常对照组子宫内膜中的表达比较,差异无统计学意义(P>0.05);ICAM-1在在位子宫内膜中的表达呈周期性变化,增生期表达高于分泌期,二者比较差异有统计学意义(P<0.05);在正常组子宫内膜的表达在增生期高于分泌期,但差异无统计学意义(P>0.05)。结论ICAM-1在子宫内膜异位症患者异位内膜中的表达升高,表明ICAM-1可能参与了子宫内膜异位症的免疫发病机制,从而为子宫内膜异位症的发病机制的研究及免疫治疗提供了广阔的前景。Objective To investigate the expression of ICAM-1 in endometriosis and then discuss its roles in the patho-genesis of endometriosis. Methods Immunohistochemistry was used to determine the expression of ICAM-1 in ectopic and eutopic edometrium from patients with EM and those from controls. Results The significantly increased expression of ICAM-1 was observed in ectopic endometrium compared with entopic and normal endometrium;there was no statistically significant difference of the expression of ICAM-1 between eutopic and normal endometriu;ICAM-1 expression showed a cyclic variation in eutopic endometrium, the staining was more abundant in the proliferative samples than in the secretory ones ; Although higher intensity staining was observed in the proliferative samples of normal endometrium compared with those in the secretory ones, there showed no significant difference （P〉0.05）. Conclusions The overexpression of ICAM-1 in the patients with endometriosis may be associated with an immunologic abnormalities in peritoneal microenviroment.Thus ,it may contribute to the progression of endometriosis.

关 键 词：子宫内膜异位症 细胞粘附分子-1 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学]