黄芩中黄酮类成分在组织损伤中抗氧化作用的研究进展  

Progress in studies of antioxidative mechanism of flavonoids extracted from Scutellaria baicalensis Georgi in tissue injury

作　　者：高平章[1] 吴洪[1] 黄俊来[1] 高中洪[2] 

机构地区：[1]泉州师范学院分子生物与药物化学福建省高校重点实验室,泉州362000 [2]华中科技大学生物无机化学与药物湖北省重点实验室,武汉430074

出　　处：《海峡药学》2009年第6期1-4,共4页Strait Pharmaceutical Journal

基　　金：国家自然科学基金项目(NO.30670481);福建省教育厅科技项目(NO.JA08209);泉州师范学院校级自选课题项目(NO.2008KJ11)

摘　　要：对黄芩中黄酮类成分抗氧化药理作用的研究进展进行综述,为开发中药抗氧化新药提供理论依据。研究表明,黄芩在脑损伤、神经细胞损伤、心肌损伤、肝损伤等疾病中具有抗氧化作用。黄芩有望开发成为安全有效的中药抗氧化新药,但对其体内抗氧化作用机制的研究需要进一步深入。The progress in the research of antioxidative mechanism of flavonoids extracted from Scutellaria baicalensis Georgi was summarized, which provides the theory basis to development new antioxidative traditional Chinese drugs. It was demonstrated by pharmacological experiments that Scutellaria baicalensis C-corgi and its extracts exhibited significant antioxidative and free-radical scavenging activities in tissue injury-including car- diomyocytes injury, liver injury, brain injury and neurocytes injury. Scutellaria baicalensis will be exploited to new antioxidative traditional Chinese drugs, however, the detailed antioxidative mechanism in vivo would study in future.

关 键 词：黄芩 黄酮 组织损伤 抗氧化 药理作用机制 

分 类 号：R285.5[医药卫生—中药学]