健心颗粒对心衰大鼠肿瘤坏死因子、白介素-6的影响  

Effect of Jianxin granule(JG) on TNF-α and IL-6 in chronic heart failure in rats

作　　者：潘娟华[1] 黄巧平[1] 高锦娟[1] 严锦贤[1] 陈美华[1] 

机构地区：[1]福建中医学院附属第二人民医院,福州350003

出　　处：《海峡药学》2009年第6期43-45,共3页Strait Pharmaceutical Journal

基　　金：福建省卫生厅青年科学研究基金课题(NO.2001)

摘　　要：目的主要探讨健心颗粒对自发性高血压大鼠(SHR)慢性心力衰竭(CHF)时的作用及机理。方法观察健心颗粒对15周龄SHR大鼠血浆肿瘤坏死因子(TNF-α)、白介素-6(IL-6)的影响。结果健心颗粒能显著降低中高剂量组TNF-α、IL-6的水平。结论健心颗粒能改善SHR大鼠心衰时神经内分泌和细胞因子水平,进而抑制心肌肥大,逆转心室重构。OBJECTIVE To investigate the mechanism of the JianXin granule （JG）in treating chronic heart failure（CHF）in spontaneously hypertensive rats（SHR） .METHODS To observe the effect of JG on TNF-α and IL-6）. RESULTS In high dose and middle dose groups of JG, the levels of TNF-α and IL-6 reduced significantly compared with the control group.CONCLUSION JianXin Granule（JG）can significantly reduced the level of TNF-α and IL-6 to prevent ventricular remodeling.

关 键 词：健心颗粒 慢性心衰 自发性高血压大鼠 

分 类 号：R97[医药卫生—药品]