穿心莲超微粉有效成分在家兔体内的药动学研究  

Pharmacokinetic Study of the Components in Ultramicro-powder of Andrographis paniculata on Rabbits

作　　者：马玉芳[1] 刘洪娜[1] 俞道进[1] 李健[1] 郑林列[1] 黄一帆[1] 

机构地区：[1]福建农林大学动物科学学院/动物保健研究所,福州350002

出　　处：《畜牧兽医学报》2009年第6期904-909,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：福建省科技厅重点项目(2004N031);福建省科技重大项目(2006NZ0003-1);福建省自然科学基金项目(BB0710002)

摘　　要：将穿心莲细粉和超微粉根据体质量以2 g.kg-1的剂量分别灌服家兔,HPLC法测定家兔体内穿心莲内酯和脱水穿心莲内酯的血药浓度,数据经PKS(Pharmaceutical Kinetics Software)药代动力学分析软件处理,比较穿心莲细粉和超微粉中2种成分的药代动力学参数。结果如下:穿心莲细粉和超微粉中的穿心莲内酯和脱水穿心莲内酯在体内的代谢过程均符合一级吸收二室模型。与细粉相比,家兔灌服超微粉后,穿心莲内酯的药时曲线下面积(AUC)提高59.86%,达峰时间(Tpeak)提前7.14 min,达峰浓度(Cmax)增大0.60%;脱水穿心莲内酯的AUC提高124.64%,Tpeak提前1.433 min,Cmax增大88.34%。上述结果表明,穿心莲经超微粉碎后,可显著提高其有效成分穿心莲内酯和脱水穿心莲内酯的生物利用度。The concentration of andrographalide and dehydroandrographolide in plasma were de- termined by HPLC in two groups of rabbits after intragastric administration with ultramicro-pul- verised powder or ordinary powder of Andrographis paniculata at a single dose （2 g ·kg-1 BW） respectively. The plasma concentration-time data of the two components above was analyzed by using Pharmaceutical Kinetics Software （PKS）. Pharmacokinetic characteristics of the two groups were compared. The results showed that both the concentration-time curves of androgra- phalide and dehydroandrographolide were confirmed to a two compartment model, compared with the ordinary powder. The area under concentration-time （AUC） was raised by 59.86%, time reaching the maximum consistency （Tpeak） was decreased by 7.14 minutes, and the maximum consistency （Cma） was enlarged by 0.60% after the rabbits were administrated with ultramicro- pulverised powder. Dehydrographoliders AUC was raised by 124.64%, Tpo.k was curtailed by 1. 433 minutes and C~.ax was enlarged by 88.34%. The results indicated that the ultromicro-pul- verization method significantly increased the bioavailability of andrographalide and dehydroan- drographolide of Andrographis paniculata.

关 键 词：穿心莲 超微粉 穿心莲内酯 脱水穿心莲内酯 药代动力学 生物利用度 

分 类 号：S859.7[农业科学—临床兽医学] S853.7[农业科学—兽医学]