2型糖尿病患者血小板参数与尿微量清蛋白及β_2-MG测定结果分析  

Study on detection of platelet parameters,microalbuminuria and β_2-MG in the datiests with type 2 diabetes

作　　者：周世亮[1] 

机构地区：[1]湖南省怀化市第一人民医院,418000

出　　处：《检验医学与临床》2009年第13期1042-1042,1044,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨2型糖尿病患者血小板参数及尿微量清蛋白(ALB)、β2-微球蛋白(β2-MG)的变化特点和临床价值。方法对54例2型糖尿病患者及39例健康成人进行血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)及ALB、β2-MG的联合对比检测。结果2型糖尿病患者与健康对照组比较,PLT差异无统计学意义(P>0.05);MPV、PDW差异均有统计学意义(P<0.01),ALB和β2-MG差异也有统计学意义(P<0.01),2型糖尿病患者的5项指标均高于健康对照组。结论血小板参数的不同变化和2型糖尿病患者微血管改变有关,ALB、β2-MG则是早期肾损害的最敏感的指标。Objective To investigate the variation of PLT.microalbuminuria.13z MG and their clinical values of the patient with stype 2 diabete. Methods PLT,MPV.PDV and microalbuminuria.β2-MG were measured in 54 patients with type 2 diabetes and 39 healthy people. Results The differences between the 2 groups are great in every item except in PLT： PLT167±44.3（P〉0.05）.MPVI3. 11±2.12（P〈0.01）,PDW15.91±1.22（P〈0.01）,urine Alb24.61 ±15.40（P〈0. 01）,β2-MG0.61±0.30（P〈0. 01）. These markers in group of type 2 diabetes were signifi- cantly higher than that of the normal controlone. Conclusion The variation of PLT markers is relevant to the changes of patients microvascular. Detection of microalbuminuria,β2-MG can provide the most impressive markers in the earlier period of kidney damage.

关 键 词：2型糖尿病 血小板参数 尿微量清蛋白 

分 类 号：R587.1[医药卫生—内分泌] R446.1[医药卫生—内科学]