肝移植患者血小板及其参数变化的临床意义  

The clinical significance of platelet and correlative parameters in liver transplanted patients

作　　者：杨瑞宁[1] 张迪[1] 王兰[1] 江淑芳[1] 

机构地区：[1]解放军第八一医院检验科,南京210002

出　　处：《检验医学与临床》2009年第13期1050-1051,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨肝移植患者血小板及其参数变化的临床意义。方法采用全自动血细胞分析仪(拜耳ADVIA2120型)测定128例肝移植术前患者、81例肝移植术后(60 d)无出血患者、13例肝移植术后有出血患者及150例健康对照者的血小板及其参数等相关指标。结果与健康对照组比较,(1)肝移植术前组血小板计数(PLT)、平均血小板体积(MPV)、血小板比容(PCT)、血小板分布宽度(PDW)差异有统计学意义(P<0.05);(2)肝移植术后无出血组PLT、MPV、PCT、PDW差异无统计学意义(P>0.05);(3)肝移植术后有出血组PLT、MPV、PCT差异有统计学意义(P<0.05),PDW差异无统计学意义(P>0.05)。与肝移植术前组比较,(1)肝移植术后无出血组PLT、MPV、PCT差异有统计学意义(P<0.01),PDW差异无统计学意义(P>0.05);(2)肝移植术后有出血组PLT、MPV、PCT、PDW差异无统计学意义(P>0.05)。肝移植术后有出血组与无出血组比较,PLT、MPV、PCT差异有统计学意义(P<0.05),PDW差异无统计学意义(P>0.05)。结论血小板及其参数相关指标的检测表明,(1)可配合临床观察肝移植术后疗效以及判断病情的变化;(2)间接反映肝移植术后PLT的恢复功能。Objective To detect the clinical significance of platelet and correlative parameters in liver transplant patients. Methods ADVIA2120 was used for detection of liver transplantation patients＇ platelet and correlative parameters, including 128 preoperative patients ; 81 postoperative patients （60 days） without . hemorrhage ; 13 postoperative patients with hemorrhage and control group. Results Compared with control group＇s PLT,MPV,PCT and PDW ： （1） There was a statistica] significance in preoperative patients （P〈 0.05） ; （2） but no significant differ- ences in postoperative patients without hemorrhage（P：〉0.05） ; （3）There was also a statistical significance in postop erative patients with hemorrhage （P^0.05） except for PDW（P^0.05）. Compared with the preoperative patients＇ PLT, MPV,PCT and PDW： （1）there was a statistical significance in postoperative patients without hemorrhage（P〈 0.01） except for PDW（P〉0.05）;（2）but no significant differences in postoperative patients with hemorrhage（P〉 0.05）. Compared with the postoperative patients without hemorrhage, PLT,MPV,PCT in hemorrhage patients has significant differences（P〈0.05） except PDW（P〈0.05）. Conclusion The detection of platelet and correlative pa rameters could help clinical doctors to observe the efficacy of liver transplantation, and judge the changes in disease; It might also reflect the function of PLT after the operation.

关 键 词：肝移植 血小板及其参数 全自动血细胞分析仪 

分 类 号：R446.11[医药卫生—诊断学]